静电纺动物蛋白纳米纤维研究进展

doi:10.13475/j.fzxb.20181206406

摘要/Abstract

摘要：

为拓展静电纺纳米纤维的应用领域,拓宽静电纺丝工艺的材料来源,对国内外近期静电纺动物蛋白纳米纤维的研究进展进行了综述。针对目前静电纺丝工艺中有机溶剂使蛋白质变性的问题,介绍了几种取代有机溶剂的方法,并对这些方法的优缺点进行对比,分析认为水溶性聚合物代替有机溶剂的方法更有利于蛋白纳米纤维在生物医药领域应用;讨论了交联改性及共混改性对静电纺动物蛋白纳米纤维力学性能的影响,对静电纺胶原蛋白纳米纤维在生物医药领域的应用进行了总结;最后针对利用静电纺丝技术制备动物蛋白纳米纤维亟待解决的问题以及未来的发展方向进行了展望。

关键词: 静电纺丝, 动物蛋白, 纳米纤维, 溶剂, 胶原蛋白

Abstract:

In order to expand the application field of electrospinning nanofibers and broaden the material sources of electrospinning process, the recent research progress of electrospinning animal protein nanofibers at home and abroad was reviewed. In view of the denaturation of protein by organic solvents in current electrospinning process, several methods of substituting organic solvents were introduced, and their advantages and disadvantages were compared. It was concluded that water-soluble polymers were more advantageous than organic solvents in the application of protein nanofibers in the field of biomedicine. The influences of cross-linking modification and blending modification on the mechanical properties of electrospun animal protein nanofibers were discussed. The application of electrospun collagen nanofibers in biomedical field was summarized. Finally, the urgent problems and future development directions of electrospun animal protein nanofibers were prospected.

Key words: electrospinning, animal protein, nanofiber, solvent, collagen protein

中图分类号:

TH16

吕婷婷, 安瑛, 李好义, 刘宇健, 焦志伟. 静电纺动物蛋白纳米纤维研究进展[J]. 纺织学报, 2019, 40(12): 140-145.

LÜ Tingting, AN Ying, LI Haoyi, LIU Yujian, JIAO Zhiwei. Research progress of electrospun animal protein nanofibers[J]. Journal of Textile Research, 2019, 40(12): 140-145.

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溶剂的选择	优点	缺点	参考文献
无毒性、环境友好型溶剂	无毒性,生物可降解性	不能保护蛋白质的活性	[16-17]
离子液体	45 ℃时胶原蛋白溶解度提升至11%	离子液价格昂贵,成本增加	[19]
同轴静电纺隔离溶剂	隔离了蛋白质与有机溶剂	装置结构复杂	[22]
水溶性聚合物与蛋白共混	以水作为溶剂,无有毒溶剂的残留	溶液浓度配比要求较高	[23]

动物胶原蛋白主要来源	胶原蛋白类型
牛皮	Ⅰ型、Ⅲ型
鸡肋软骨	Ⅱ型
鼠尾腱	Ⅰ型
山羊皮	Ⅰ型、Ⅲ型