载药聚偏氟乙烯伤口敷料的制备及其性能

doi:10.13475/j.fzxb.20190200306

纺织学报 ›› 2020, Vol. 41 ›› Issue (01): 26-31.doi: 10.13475/j.fzxb.20190200306

载药聚偏氟乙烯伤口敷料的制备及其性能

吴倩倩¹^,², 李珂¹, 杨立双¹, 付译鋆¹^,²(), 张瑜¹^,², 张海峰¹^,²

1.南通大学纺织服装学院, 江苏南通 226019
2.南通大学安全防护用特种纤维复合材料研发国家地方联合工程研究中心, 江苏南通 226019

收稿日期:2019-01-29 修回日期:2019-10-24 出版日期:2020-01-15 发布日期:2020-01-14
通讯作者: 付译鋆
作者简介:吴倩倩(1995—),女,硕士生。主要研究方向为非织造医用材料。
基金资助:
江苏省自然科学基金项目(BK20190927);江苏省博士后日常资助项目(2019Z104);南通大学大学生创新训练计划项目(2019111);南通市科技计划项目(MS12018005);南通大学人才引进科研启动项目(17R19)

Preparation and properties of drug-loaded polyvinylidene fluoride wound dressings

WU Qianqian¹^,², LI Ke¹, YANG Lishuang¹, FU Yijun¹^,²(), ZHANG Yu¹^,², ZHANG Haifeng¹^,²

1. School of Textile and Clothing, Nantong University, Nantong, Jiangsu 226019, China
2. National & Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection,Nantong University, Nantong, Jiangsu 226019, China

Received:2019-01-29 Revised:2019-10-24 Online:2020-01-15 Published:2020-01-14
Contact: FU Yijun

摘要/Abstract

摘要：

为获得轻薄柔软的伤口敷料,并使其具备优异的压电和抗菌性能,以聚偏氟乙烯(PVDF)为原料,掺杂不同质量分数的盐酸恩诺沙星(Enro),采用静电纺丝技术制备载药PVDF复合纳米纤维膜。分析了复合纳米纤维膜的形貌、化学结构对其压电性能、药物缓释和抗菌性能的影响。结果表明:PVDF质量分数为8%时,纤维平均直径为(753±128) nm,纤维网成膜良好,复合纳米纤维膜直径随着Enro质量分数的增加呈先增大后减小趋势;纺丝过程中PVDF由α晶型转变为β晶型,使纤维膜具备了压电性能,可产生9 mV的输出电压;当 Enro质量分数为15%时,纤维膜释药速度平稳、持续时间长且具备优异的抗菌性能,适合用作伤口敷料。

关键词: 伤口敷料, 聚偏氟乙烯, 恩诺沙星, 静电纺丝, 压电性能, 抗菌性能

Abstract:

With the aim of obtaining thin and soft wound dressings with excellent piezoelectric and antibacterial functions, drug-loaded (PVDF) composite nanofiber membranes were prepared by electrospinning from PVDF and enrofloxacin hydrochloride (Enro) at different mass ratios. The influence of morphology and chemical structure of the composite nanofiber membrane on its piezoelectricity, sustained release and antibacterial properties were investigated. Results show that in the situation where the mass ratio of PVDF was 8% and the average fiber diameter was(753±128) nm, the fiber membrane showed good web formation. It is revealed that the diameter of composite nanofiber increased and then decreased as the Enro mass fraction was incremented, and that the crystal structure of PVDF changed from α to β crystal phase after the process of electrospinning, leading to an excellent piezoelectric properties with a 9 mV output voltage. When the mass concentration of Enro was 15%, the drug-loaded PVDF composite nanofiber membrane exhibited a relatively stable and sustainable release and outstanding antibacterial performance. The drug-loaded PVDF composite nanofiber membrane is proven to be suitable for wound dressings.

Key words: wound dressings, polyvinylidene fluoride, enrofloxacin hydrochloride, electrospinning, piezoelectric property, antibacterial property

中图分类号:

TS174.8

吴倩倩, 李珂, 杨立双, 付译鋆, 张瑜, 张海峰. 载药聚偏氟乙烯伤口敷料的制备及其性能[J]. 纺织学报, 2020, 41(01): 26-31.

WU Qianqian, LI Ke, YANG Lishuang, FU Yijun, ZHANG Yu, ZHANG Haifeng. Preparation and properties of drug-loaded polyvinylidene fluoride wound dressings[J]. Journal of Textile Research, 2020, 41(01): 26-31.

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载药聚偏氟乙烯伤口敷料的制备及其性能

Preparation and properties of drug-loaded polyvinylidene fluoride wound dressings

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