聚乙烯醇/海藻酸钠/黄连素医用敷料制备及其性能

doi:10.13475/j.fzxb.20200605207

摘要/Abstract

摘要：

为提高聚乙烯醇(PVA)/海藻酸钠(SA)医用敷料的抗菌性和耐水性能,采用黄连素(BR)为天然抗菌剂负载在医用敷料上,通过静电纺丝法制备PVA/SA/BR纳米纤维膜,并在氯化钙无水乙醇溶液中进行交联处理,对PVA/SA/BR纳米纤维膜的化学结构、抗菌性能、吸液性能以及力学性能进行表征与分析。结果表明:BR负载在PVA/SA纳米纤维上形成明显串珠,且与PVA/SA结合良好,氯化钙交联处理后PVA/SA/BR纳米纤维膜由网状变为平滑膜状;当BR质量分数为6%时,PVA/SA/BR纳米纤维膜断裂强度为1.76 MPa,其对大肠杆菌和金黄色葡萄球菌的抑菌率分别为99.41%、97.89%;当氯化钙质量分数为4%,交联时间为4 h时,PVA/SA/BR纳米纤维膜的断裂强度为4.17 MPa,吸液倍率为1 257%。

关键词: 医用敷料, 黄连素, 氯化钙交联, 抗菌性, 耐水性能, 纳米纤维膜

Abstract:

In order to improve the antibacterial and water resistance of polyvinyl alcohol (PVA)/sodium alginate (SA) medical dressings, berberine (BR) was used as a natural antibacterial agent to load on the medical dressing. The PVA/SA/BR nanofiber membrane was prepared by electrostatic spinning, and the membrane was cross-linked in calcium chloride absolute ethanol solution. The chemical structure, antibacterial performance, liquid absorption and mechanical properties of the PVA/SA/BR nanofiber membrane were characterized and analyzed. The results show obvious beads of BR in PVA/SA nanofiber,which combine well with PVA/SA. After cross-linking with calcium chloride, the PVA/SA/BR nanofiber membrane changes from mesh to smooth membrane. When the mass fraction of berberine is 6%, the breaking strength of the PVA/SA/BR nanofiber membrane is 1.76 MPa, and the antibacterial rates for Escherichia coli and Staphylococcus aureus are 99.41% and 97.89% repspectively. When the mass fraction of calcium chloride is 4% and the cross-linking time is 4 h, the breaking strength of the PVA/SA/BR nanofiber membrane is 4.17 MPa and the liquid absorption rate is 1 257%.

Key words: medical dressing, berberine, calcium chloride cross-linking, antibacterial property, water resistance, nanofiber membrane

中图分类号:

TQ340.64

王春红, 李明, 龙碧旋, 才英杰, 王利剑, 左祺. 聚乙烯醇/海藻酸钠/黄连素医用敷料制备及其性能[J]. 纺织学报, 2021, 42(05): 16-22.

WANG Chunhong, LI Ming, LONG Bixuan, CAI Yingjie, WANG Lijian, ZUO Qi. Preparation and performance of polyvinyl alcohol/sodium alginate/berberine medical dressing[J]. Journal of Textile Research, 2021, 42(05): 16-22.

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