纺织学报 ›› 2022, Vol. 43 ›› Issue (07): 193-199.doi: 10.13475/j.fzxb.20201207107

• 综合述评 • 上一篇    下一篇

伤口修复中抑制瘢痕用功能敷料的研究进展

宋子钰1, 赵居阳1, 秦玥1, 黄小睿1, 高晶1,2(), 王璐1,2   

  1. 1.东华大学 纺织学院, 上海 201620
    2.东华大学 纺织行业生物医用纺织材料与技术重点实验室, 上海 201620
  • 收稿日期:2020-12-28 修回日期:2021-05-31 出版日期:2022-07-15 发布日期:2022-07-29
  • 通讯作者: 高晶
  • 作者简介:宋子钰(1997—),女,博士生。主要研究方向为纺织材料与纺织品设计。

Research progress in functional dressings for scar inhibition in wound healing

SONG Ziyu1, ZHAO Juyang1, QIN Yue1, HUANG Xiaorui1, GAO Jing1,2(), WANG Lu1,2   

  1. 1. College of Textiles, Donghua University, Shanghai 201620, China
    2. Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, Donghua University, Shanghai 201620, China
  • Received:2020-12-28 Revised:2021-05-31 Published:2022-07-15 Online:2022-07-29
  • Contact: GAO Jing

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摘要：

为实现皮肤伤口的无疤愈合,针对功能敷料在皮肤伤口愈合中所起到的抑制瘢痕作用,对国内外的相关研究进行概括总结。以伤口愈合过程为切入点,从瘢痕形成的影响因素,即外部环境和内部生物信号调控入手,系统分析了伤口愈合不同阶段的不同生理环境和需求下对抑制瘢痕敷料的性能要求。在炎症期、增殖期和重塑期3个阶段中,功能敷料分别以降低炎症反应、调节信号传导和促进组织再生的作用机制来抑制瘢痕的产生。认为瘢痕形成是一个动态连续而又复杂的过程,该过程涉及炎症细胞、角质形成细胞、成纤维细胞以及各类生长因子等物质,指出用于抑制瘢痕的功能敷料要想达到更好的效果,需要注重新型给药系统的研究和敷料结构的优化设计。

关键词: 功能敷料, 抑制瘢痕, 炎症反应, 成纤维细胞, TGF-β/Smad信号, 细胞外基质, 胶原蛋白

Abstract:

In order to achieve scarless cutaneous wound healing, a summary of the relevant researches at home and abroad on the effect of functional dressings on inhibiting scarring was reviewed and summarized. The wound healing process was reviewed in the first place, concentrating on the factors affecting scar formation, namely external environment and internal biological signal regulation, the performance requirements of scar-inhibiting dressings under different physiological environments and demands at different stages of wound healing. At the three stages of inflammation, proliferation and remodeling, functional dressings inhibit scarring by reducing inflammatory response, regulating signal transduction and promoting tissue regeneration, respectively. Studies have shown that scar formation is a dynamic, continuous and complex process involving inflammatory cells, keratinocytes, fibroblasts and various growth factors. Therefore, in order to achieve better effect of functional dressings used to suppress scars, it is necessary to pay attention to the research of new drug delivery systems and the optimal design of dressings structures.

Key words: functional dressing, scar inhibition, inflammatory response, fibroblast, TGF-β/Smad signal, extracellular matrix, collagen

中图分类号: 

  • TS101.4

图1

炎症反应对瘢痕形成的影响机制"

图2

TGF-β/Smad信号通路"

表1

伤口愈合各阶段的抑制瘢痕措施"

愈合阶段 目的 相关因素 实现方式 参考文献
炎症期 降低炎症反应 炎症细胞多 抗菌 [4,15⇓⇓⇓-19]
氧气少 抗氧化 [20-21]
增殖期 调控信号传导 角质形成细胞与成纤维细胞间的信号通路 保持创面湿润 [23⇓⇓-26,29,31]
TGF-β/Smad信号通路 阻断信号传导 [1,7,32⇓⇓⇓-36]
重塑期 促进组织再生 成纤维细胞增殖分化 控制分化 [38⇓-40]
ECM变化 增加胶原酶活性,控制Ⅰ/Ⅲ型胶原合成 [37,41⇓⇓-44,49-50]
血管和皮肤附属物缺失 促进血管生成和正常皮肤组织再生 [45⇓⇓-48]
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