纺织学报 ›› 2022, Vol. 43 ›› Issue (06): 9-14.doi: 10.13475/j.fzxb.20210804806

• 高性能纺织结构柔性材料制备及应用 • 上一篇    下一篇

金属酚醛/两性离子聚合物涂层聚丙烯补片的制备及其抗蛋白吸附性能

王茜1,2, 乔燕莎1,2, 王君硕1, 李彦1,2,3(), 王璐1,2,3   

  1. 1.东华大学 纺织学院, 上海 201620
    2.东华大学 纺织面料技术教育部重点实验室, 上海 201620
    3.东华大学 纺织行业生物医用纺织材料与技术重点实验室, 上海 201620
  • 收稿日期:2021-08-10 修回日期:2022-01-14 出版日期:2022-06-15 发布日期:2022-07-15
  • 通讯作者: 李彦
  • 作者简介:王茜(1997—),女,硕士生。主要研究方向为生物医用疝修补片。
  • 基金资助:
    中央高校基本科研业务费专项资金项目(2232020G-01);高等学校学科创新引智计划项目(BP0719035);国家重点研发计划项目(2016YFB0303300)

Preparation of metal phenolic network/zwitterionic polymer coated polypropylene mesh and its resistance to protein adsorption

WANG Qian1,2, QIAO Yansha1,2, WANG Junshuo1, LI Yan1,2,3(), WANG Lu1,2,3   

  1. 1. College of Textiles, Donghua University, Shanghai 201620, China
    2. Key Laboratory of Textile Science & Technology of Ministry of Education, Donghua University, Shanghai 201620, China
    3. Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China
  • Received:2021-08-10 Revised:2022-01-14 Published:2022-06-15 Online:2022-07-15
  • Contact: LI Yan

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摘要：

为将亲水两性离子材料与惰性聚丙烯(PP)补片有效结合,降低蛋白质在补片表面的吸附,利用三价铁离子和单宁酸(TA)层层自组装的金属酚醛网络(MPN),介导聚羧酸甜菜碱甲基丙烯酸酯(PCBMA)固定在PP补片上,对该改性涂层补片的微观形貌、表面成分、接触角、表面电位、力学性能、抗蛋白吸附性能和细胞毒性进行表征与分析。结果表明:MPN可将PCBMA均匀固定在单丝表面,改变补片的表面化学组成;PCBMA-Fe/TA涂层将PP表面的水接触角降低至37°,表面电位由-55.7 mV提高到-5.14 mV;涂层不影响PP补片的力学性能,并为补片带来了显著的抗蛋白吸附效果;改性补片的相对细胞活力达到89%,表现出良好的生物相容性。研究结果有望为惰性医疗器械的抗污改性提供参考。

关键词: 聚丙烯补片, 单宁酸, 金属酚醛网络, 层层自组装, 两性离子, 抗蛋白吸附性能

Abstract:

In order to combine hydrophilic zwitterions with inert polypropylene (PP) mesh and reduce the adsorption of protein on the mesh surface, poly(carboxybetaine methacrylate) (PCBMA) was deposited on PP mesh through Fe(Ⅲ) and tannic acid (TA) layer-by-layer self-assembly of metal phenolic network (MPN). The micro-morphology, surface composition, contact angle, surface potential, mechanical properties, protein adsorption properties and cytotoxicity of the meshes before and after modification were characterized and analyzed. The results show that PCBMA can wrap evenly on the surface of PP monofilament assisted by MPN, and the surface chemical composition of the mesh is changed. Moreover, PCBMA-Fe/TA coating reduces the water contact angle of the mesh to 37° and the surface zeta potential is increased from -55.7 mV to -5.14 mV. In addition, the mechanical properties of PP mesh are not affected by the coating, but the coating brings significant protein adsorption resistance to the mesh. Furthermore, the relative cell viability of the modified mesh reaches 89%, which shows excellent biocompatibility. In general, the study provides a reference basis for the antifouling modification of inert medical devices.

Key words: polypropylene mesh, tannic acid, metal phenolic network, layer-by-layer, zwitterionic, protein adsorption resistance

中图分类号: 

  • R318.0

图1

PP、Fe/TA-PP和PCBMA-Fe/TA-PP的SEM照片"

图2

PCBMA的核磁共振氢谱图"

图3

PCBMA-Fe/TA-PP的X射线光电子能谱图"

图4

PP、Fe/TA-PP和PCBMA-Fe/TA-PP的红外光谱图"

图5

改性前后补片的水接触角变化"

图6

改性前后补片的表面Zeta电位变化"

表1

改性前后补片的力学性能"

试样名称 断裂强度/(N·cm-1) 断裂伸长率/%
横向 纵向 横向 纵向
PP 50.9±0.6 48.1±2.3 61.8±0.8 90.0±1.7
Fe/TA-PP 51.1±0.5 50.3±1.6 59.8±1.3 92.4±1.4
PCBMA-Fe/TA-PP 53.2±0.8 50.8±1.9 61.9±1.4 93.1±1.2

图7

BSA-FITC标记的补片荧光图像"

表2

小鼠成纤维细胞在24 h的CCK-8吸光度"

试样名称 CCK-8吸光度值
空白对照 0.53±0.05
PP 0.51±0.06
PCBMA-Fe/TA-PP 0.47±0.06
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