纺织学报 ›› 2025, Vol. 46 ›› Issue (01): 206-216.doi: 10.13475/j.fzxb.20240103502

• 综合述评 • 上一篇    下一篇

熔体近场直写制备组织工程支架的研究进展

杨柳1,2, 杜磊1(), 徐淮中2   

  1. 1.浙江理工大学 服装学院, 浙江 杭州 310018
    2.京都工艺纤维大学 生物基材料科学学院, 日本 京都 606-8585
  • 收稿日期:2024-01-18 修回日期:2024-10-09 出版日期:2025-01-15 发布日期:2025-01-15
  • 通讯作者: 杜磊(1989—),男,副教授,博士。主要研究方向为生物医用纤维材料开发。E-mail:dulei@zstu.edu.cn。
  • 作者简介:杨柳(1998—),女,博士生。主要研究方向为生物医用纤维材料开发。
  • 基金资助:
    国家自然科学基金项目(52403054);浙江省重点研发计划项目(2023C01196);杭州市卫生科技计划重大项目(Z20230087);国家留学基金项目(202007295002);国家留学基金项目(202308330110)

Research progress in tissue engineering scaffolds fabricated by melt electrowriting technology

YANG Liu1,2, DU Lei1(), XU Huaizhong2   

  1. 1. School of Fashion Design & Engineering, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China
    2. Department of Biobased Materials Science, Kyoto Institute of Technology, Kyoto 606-8585, Japan
  • Received:2024-01-18 Revised:2024-10-09 Published:2025-01-15 Online:2025-01-15

RichHTML

7

PDF (PC)

22

摘要：

熔体近场直写(MEW)作为一种新兴的增材制造技术,可在微米尺度下实现纤维支架结构的精准构筑。为进一步推动该技术在组织工程领域的应用,综述了近年来国内外MEW技术的研究进展。针对MEW设备组成,详解了各模块的工作原理和设计思路;针对MEW射流调控,阐述了射流稳定及沉积过程中的成形机制与控制机制;针对MEW技术的应用场景,讨论了不同结构支架的构筑方法及其构效关系;此外,还总结了MEW技术与其它技术结合的典型范例;最后,展望了MEW技术的发展方向,以期为其在多领域交叉融合发展提供理论支撑和应用参考。

关键词: 熔体近场直写, 增材制造, 高分辨率打印, 射流控制, 组织工程, 纤维支架

Abstract:

Significance Melt electrowriting (MEW) technology is an emerging and promising additive manufacturing technology that allows for precise control of scaffold structure while maintaining the microscale of fibers. With the assistance of electrical power and collector translation (or mandrel rotation), scaffolds with controllable structures and high-precision can be fabricated. MEW has been demonstrated to have the potential to be used as bone tissue engineering scaffolds, heart valve scaffolds, and vascular scaffolds. The prepared scaffolds exhibit excellent mechanical properties, effectively promote extracellular matrix formation while supporting cell attachment and proliferation. These characteristics facilitate orderly cellular behaviors and differentiation, ultimately enhancing tissue regeneration. In addition, MEW has been combined with other technologies to promote the biological properties of the scaffolds, helping to broaden the scope of MEW applications in the field of tissue engineering scaffolds. This integration improves mechanical strength and broadens the scope of MEW applications in tissue engineering by enabling the creation of hybrid structures with tailored functionalities.

Progress Based on the current MEW technology and fiber forming mechanisms, this paper provides a detailed review of the research progress in MEW technology for the preparation of tissue engineering scaffolds. Based on the characteristics of MEW technology, this paper scrutinizes MEW from the aspects of equipment composition, printing regulation, and structural design. The multi-parameter characteristics of MEW and the dynamic relationship between printing parameters directly affect the printing quality. During the printing process, some phenomena affecting the quality of the printed scaffolds, such as fiber pulsing, fiber bridging, and fiber shifting, would occur. In order to avoid these undesirable phenomena, precise printing of tissue engineering scaffolds can be achieved by adjusting the cooperation of each parameter. For the tissue engineering scaffolds, this paper introduces them as planar scaffolds and non-planar scaffolds, in which planar scaffolds are divided into homogeneous scaffolds and heterogeneous scaffolds. The non-planar scaffolds are categorized into tubular scaffolds, which have been a research hotspot in recent years, and scaffolds obtained from other non-planar receiving devices. For the combination of MEW technology with other technologies, this paper mainly introduces the combination of MEW technology with fused deposition modeling (FDM), electrospinning, and hydrogel. For the biological applications of MEW technology, this paper focuses on its use in bone tissue engineering, heart valves, tendons, blood vessels, renal tubules, and other fields.

Conclusion and Prospect To further promote the application of MEW in the field of tissue engineering, this paper covers the research progress in MEW technology in recent years. Owing to its capability to achieve precise control of the scaffold structure at the microscale, this technology has expanded the application of fiber scaffolds in the biomedical field. However, some issues still existo that need to be addressed. 1) Material range: the range of printable materials for MEW is essential. Currently, most of the current research still revolves around the polymer polycaprolactone due to its low melting point and high thermal stability. However, its degradation rate and Young's modulus present compatibility challenges for clinical applications. Therefore, expanding the application of MEW printed polymer is imperative to promote the practical application of tissue engineering scaffolds. 2) Thermal degradation control: controlling the thermal degradation rate of MEW-printed materials remains challenging due to minimal melt extrusion volume and prolonged heating processing. although a filament-based feeding system inspired by FDM printers has been developed, its widespread applicability is yet to be proven. 3) Customization of complex scaffolds: MEW utilizes an electrostatic field to create fibers, but jet initiation time limits design flexibility compared to FDM. Further research is needed on path planning to achieve precise printing of complex scaffolds under uninterrupted jet flow conditions. 4) Clinical validation: although functional scaffolds for bone tissue engineering and heart valve scaffolds have been fabricated, clinical validation has yet to be achieved. The mechanisms underlying tissue repair and the practical application effects of their work still require further exploration and clarification. As the research progresses, it is believed that the MEW technology can be extended to many tissue engineering applications in the coming years.

Key words: melt electrowriting, additive manufacturing, high resolution printing, jet control, tissue engineering, fiber scaffold

中图分类号: 

  • TS151

图1

熔体近场直写装置"

图2

熔体近场直写特殊现象"

图3

不同结构支架与应用"

[1] BROWN Toby D, DALTON Paul D, HUTMACHER Dietmar W. Direct writing by way of melt electro-spinning[J]. Advanced Materials, 2011, 23(47): 5651-5657.
[2] EICHHOLZ Kian F, GONÇALVES Inês, BARCELÓ Xavier, et al. How to design, develop and build a fully-integrated melt electrowriting 3D printer[J]. Additive Manufacturing, 2022. DOI: 10.1016/j.addma.2022.102998.
[3] LU Huali, SUN Yue, CHEN Yufei, et al. The effects of voltage configurations on print accuracy in melt electrowriting[J]. Materials Letters, 2023. DOI: 10.1016/j.matlet.2022.133738.
[4] TOURLOMOUSIS Filippos, DING Houzhu, KALYON Dilhan M, et al. Melt electrospinning writing process guided by a ″Printability Number″[J]. Journal of Manufacturing Science and Engineering, 2017. DOI: 10.1115/1.4036348.
[5] HE Jiankang, XIA Peng, LI Dichen. Development of melt electrohydrodynamic 3D printing for complex microscale poly (ε-caprolactone) scaffolds[J]. Biofabrication, 2016. DOI: 10.1088/1758-5090/8/3/035008.
[6] ZHANG Fucheng, CAO Kai, ZAERI Ahmadreza, et al. Effects of scaffold design parameters on the printing accuracy for melt electrowriting[J]. Journal of Manufacturing Processes, 2022, 81: 177-190.
[7] HOCHLEITNER Gernot, HÜMMER Julia Franziska, LUXENHOFER Robert, et al. High definition fibrous poly(2-ethyl-2-oxazoline) scaffolds through melt electrospinning writing[J]. Polymer, 2014, 55(20): 5017-5023.
[8] MIESZCZANEK Pawel, ROBINSON Thomas M, DALTON Paul D, et al. Convergence of machine vision and melt electrowriting[J]. Advanced Materials, 2021. DOI: 10.1002/adma.202100519.
[9] HOCHLEITNER Gernot, YOUSSEF Almoatazbellah, HRYNEVICH Andrei, et al. Fibre pulsing during melt electrospinning writing[J]. BioNanoMaterials, 2016, 17(3/4): 159-171.
[10] NADERNEZHAD Ali, RYMA Matthias, GENÇ Hatice, et al. Melt electrowriting of isomalt for high-resolution templating of embedded microchannels[J]. Advanced Materials Technologies, 2021. DOI: 10.1002/admt.202100221.
[11] CAO Kai, ZHANG Fucheng, WANG Bijun, et al. Analytical interpretation of microscale fiber deviation in designing for polymer melt electrohydrodynamic-based additive manufacturing[J]. Additive Manufacturing, 2022. DOI: 10.1016/j.addma.2022.103035.
[12] XU Huaizhong, LIASHENKO Ievgenii, LUCCHETTI Agnese, et al. Designing with circular arc toolpaths to increase the complexity of melt electrowriting[J]. Advanced Materials Technologies, 2022. DOI: 10.1002/admt.202101676.
[13] ROBINSON Thomas M, HUTMACHER Dietmar W, DALTON Paul D. The next frontier in melt electrospinning: taming the jet[J]. Advanced Functional Materials, 2019. DOI: 10.1002/adfm.201904664.
[14] SU Yingchun, ZHANG Zhongyang, WAN Yilin, et al. A hierarchically ordered compacted coil scaffold for tissue regeneration[J]. NPG Asia Materials, 2020. DOI: 10.1038/s41427-020-0234-7.
[15] KIM Jaehyeon, BAKIRCI Ezgi, O'NEILL Kelly L, et al. Fiber bridging during melt electrowriting of poly (ε-caprolactone) and the influence of fiber diameter and wall height[J]. Macromolecular Materials and Engineering, 2021. DOI: 10.1002/mame.202000685.
[16] DU Lei, YANG Liu, LU Huali, et al. Additive manufacturing of ultrahigh-resolution poly(ε-caprolactone) scaffolds using melt electrowriting[J]. Polymer, 2024. DOI: 10.1016/j.polymer.2024.127028.
[17] HE Jiankang, HAO Guanzhe, MENG Zijie, et al. Expanding melt-based electrohydrodynamic printing of highly-ordered microfibrous architectures to cm-height via in situ charge neutralization[J]. Advanced Materials Technologies, 2022. DOI: 10.1002/admt.202101197.
[18] LIASHENKO Ievgenii, HRYNEVICH Andrei, DALTON Paul D. Designing outside the box: unlocking the geometric freedom of melt electrowriting using microscale layer shifting[J]. Advanced Materials, 2020. DOI: 10.1002/adma.202001874.
[19] MENG Jie, BOSCHETTO Francesco, YAGI Shinichi, et al. Design and manufacturing of 3D high-precision micro-fibrous poly (L-lactic acid) scaffold using melt electrowriting technique for bone tissue engineering[J]. Materials and Design, 2021. DOI: 10.1016/j.matdes.2021.110063.
[20] NGUYEN Nhat Tung, KIM Jeong Hwa, JEONG Young Hun. Identification of sagging in melt-electrospinning of microfiber scaffolds[J]. Materials Science and Engineering: C, 2019. DOI: 10.1016/j.msec.2019.109785.
[21] HRYNEVICH Andrei, ACHENBACH Pascal, JUNGST Tomasz, et al. Design of suspended melt electrowritten fiber arrays for Schwann cell migration and neurite outgrowth[J]. Macromolecular Bioscience, 2021. DOI: 10.1002/mabi.202000439.
[22] BERTLEIN Sarah, HIKIMOTO Daichi, HOCHLEITNER Gernot, et al. Development of endothelial cell networks in 3D tissues by combination of melt electrospinning writing with cell-accumulation technology[J]. Small, 2018. DOI: 10.1002/smll.201701521.
[23] CASTILHO Miguel, FEYEN Dries, FLANDES-IPARRAGUIRRE María, et al. Melt electrospinning writing of poly-hydroxymethylglycolide-co-ε-caprolactone-based scaffolds for cardiac tissue engineering[J]. Advanced Healthcare Materials, 2017. DOI: 10.1002/adhm.201700311.
[24] CASTILHO Miguel, VAN MIL Alain, MAHER Malachy, et al. Melt electrowriting allows tailored microstructural and mechanical design of scaffolds to advance functional human myocardial tissue formation[J]. Advanced Functional Materials, 2018. DOI: 10.1002/adfm.201803151.
[25] CEDILLO-SERVIN Gerardo, DAHRI Ouafa, MENESES João, et al. 3D printed magneto-active microfiber scaffolds for remote stimulation and guided organization of 3D in vitro skeletal muscle models[J]. Small, 2023. DOI: 10.1002/smll.202307178.
[26] MONDADORI Carlotta, CHANDRAKAR Amit, LOPA Silvia, et al. Assessing the response of human primary macrophages to defined fibrous architectures fabricated by melt electrowriting[J]. Bioactive Materials, 2023(21): 209-222.
[27] LI Sicheng, HUANG Jinjian, XU Ziyan, et al. Melt electrowriting-printed peritoneal scaffold prevents peritoneal adhesion and facilitates peritoneal repair[J]. International Journal of Bioprinting, 2023. DOI: 10.18063/ijb.682.
[28] DAGHRERY Arwa, FERREIRA Jessica A, DE SOUZA Araújo Isaac J, et al. A highly ordered, nanostructured fluorinated CaP-coated melt electrowritten scaffold for periodontal tissue regeneration[J]. Advanced Healthcare Materials, 2021. DOI: 10.1002/adhm.202101152.
[29] BARCELÓ Xavier, EICHHOLZ Kian F, GONÇALVES Inês F, et al. Bioprinting of structurally organized meniscal tissue within anisotropic melt electrowritten scaffolds[J]. Acta Biomaterialia, 2023, 158: 216-227.
[30] BAS Onur, D'ANGELLA Davide, BALDWIN Jeremy G, et al. An integrated design, material, and fabrication platform for engineering biomechanically and biologically functional soft tissues[J]. ACS Applied Materials and Interfaces, 2017, 9(35): 29430-29437.
[31] SAIDY Navid T, WOLF Frederic, BAS Onur, et al. Biologically inspired scaffolds for heart valve tissue engineering via melt electrowriting[J]. Small, 2019. DOI: 10.1002/smll.201900873.
[32] OLVERA Dinorath, SOHRABI MOLINA Mina, HENDY Gillian, et al. Electroconductive melt electrowritten patches matching the mechanical anisotropy of human myocardium[J]. Advanced Functional Materials, 2020. DOI: 10.1002/adfm.201909880.
[33] SHAFIEE Abbas, CAVALCANTI Amanda S, SAIDY Navid T, et al. Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy[J]. Biomaterials, 2021. DOI: 10.1016/j.biomaterials.2020.120558.
[34] MATHEW Asha, DEVLIN Brenna L, SINGH Dilpreet, et al. Improving infection resistance in tissue engineered scaffolds for tensile applications using vancomycin-embedded melt electrowritten scaffolds[J]. Macromolecular Materials and Engineering, 2023. DOI: 10.1002/mame.202300168.
[35] YANG Liu, LOU Yi, ZHANG Guoping, et al. Hybrid manufacturing of highly stretchable functionalized membrane for joint wound treatment[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024. DOI: 10.1016/j.colsurfa.2023.132655.
[36] JIN Yuan, GAO Qing, XIE Chaoqi, et al. Fabrication of heterogeneous scaffolds using melt electrospinning writing: design and optimization[J]. Materials and Design, 2020. DOI: 10.1016/j.matdes.2019.108274.
[37] XIE Chaoqi, GAO Qing, WANG Peng, et al. Structure-induced cell growth by 3D printing of heterogeneous scaffolds with ultrafine fibers[J]. Materials and Design, 2019. DOI: 10.1016/j.matdes.2019.108092.
[38] VERNON Michael J, LU Jason, PADMAN Benjamin, et al. Engineering heart valve interfaces using melt electrowriting: biomimetic design strategies from multi-modal imaging[J]. Advanced Healthcare Materials, 2022. DOI: 10.1002/adhm.202201028.
[39] ABBASI Naghmeh, LEE Ryan S B, IVANOVSKI Saso, et al. In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds[J]. Biomaterials Research, 2020. DOI: 10.1186/s40824-020-00196-1.
[40] GOLAFSHAN Nasim, CASTILHO Miguel, DAGHRERY Arwa, et al. Composite graded melt electrowritten scaffolds for regeneration of the periodontal ligament-to-bone interface[J]. ACS Applied Materials and Interfaces, 2023, 15(10): 12735-12749.
[41] PAXTON Naomi C, LUPOSCHAINSKY Simon, REIZABAL Ander, et al. Manufacture of biomimetic auricular surgical implants using 3D printed high density polyethylene microfibers[J]. Advanced Materials Technologies, 2023. DOI: 10.1002/admt.202301190.
[42] BROWN Toby D, SLOTOSCH Anna, THIBAUDEAU Laure, et al. Design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode[J]. Biointerphases, 2012. DOI: 10.1007/s13758-011-0013-7.
[43] MCCOLL Erin, GROLL Jürgen, JUNGST Tomasz, et al. Design and fabrication of melt electrowritten tubes using intuitive software[J]. Materials and Design, 2018, 155: 46-58.
[44] ZHANG Fucheng, CAO Kai, ZAERI Ahmadreza, et al. Design, fabrication, and characterization of tubular scaffolds by way of a melt electrowriting process[J]. Additive Manufacturing, 2023. DOI: 10.1016/j.addma.2022.103383.
[45] PAXTON Naomi C, DALEY Ryan, FORRESTAL David P, et al. Auxetic tubular scaffolds via melt electrowriting[J]. Materials and Design, 2020. DOI:10.1016/j.matdes.2020.108787.
[46] MCCOSKER Audrey B, SNOWDON Mikayla E, LAMONT Riki, et al. Exploiting nonlinear fiber patterning to control tubular scaffold mechanical behavior[J]. Advanced Materials Technologies, 2022. DOI: 10.1002/admt.202200259.
[47] SOMSZOR Katarzyna, BAS Onur, KARIMI Fatemeh, et al. Personalized, mechanically strong, and biodegradable coronary artery stents via melt electrowriting[J]. ACS Macro Letters, 2020, 9(12): 1732-1739.
[48] SAIDY Navid T, SHABAB Tara, BAS Onur, et al. Melt electrowriting of complex 3D anatomically relevant scaffolds[J]. Frontiers in Bioengineering and Biotechnology, 2020. DOI: 10.3389/fbioe.2020.00793.
[49] SAIDY Navid Toosi, FERNÁNDEZ-COLINO Alicia, HEIDARI Behzad Shiroud, et al. Spatially heterogeneous tubular scaffolds for in situ heart valve tissue engineering using melt electrowriting[J]. Advanced Functional Materials, 2022. DOI: 10.1002/adfm.202110716.
[50] WEEKES Angus, WEHR Gabrielle, PINTO Nigel, et al. Highly compliant biomimetic scaffolds for small diameter tissue-engineered vascular grafts (TEVGs) produced via melt electrowriting (MEW)[J]. Biofabrication, 2023. DOI: 10.1088/1758-5090/ad0ee1.
[51] PEIFFER Quentin C, DE RUIJTER Mylène, VAN DUIJN Joost, et al. Melt electrowriting onto anatomically relevant biodegradable substrates: Resurfacing a diarthrodial joint[J]. Materials and Design, 2020. DOI: 10.1016/j.matdes.2020.109025.
[52] SAHA Uttariyo, NAIRN Rory, KEENAN Orla, et al. A deeper insight into the influence of the electric field strength when melt-electrowriting on non-planar surfaces[J]. Macromolecular Materials and Engineering, 2021. DOI: 10.1002/mame.202100496.
[53] LUPOSCHAINSKY Simon, JÖRISSEN Sven, NÜCHTER Andreas, et al. Melt electrowriting of poly(dioxanone) filament using a multi-axis robot[J]. Macromolecular Materials and Engineering, 2022. DOI: 10.1002/mame.202200450.
[54] QIAO Zhiguang, LIAN Meifei, HAN Yu, et al. Bioinspired stratified electrowritten fiber-reinforced hydrogel constructs with layer-specific induction capacity for functional osteochondral regeneration[J]. Biomaterials, 2021. DOI: 10.1016/j.biomaterials.2020.120385.
[55] GAO Qing, XIE Chaoqi, WANG Peng, et al. 3D printed multi-scale scaffolds with ultrafine fibers for providing excellent biocompatibility[J]. Materials Science and Engineering: C, 2020. DOI: 10.1016/j.msec.2019.110269.
[56] JIN Yuan, XIE Chaoqi, GAO Qing, et al. Fabrication of multi-scale and tunable auxetic scaffolds for tissue engineering[J]. Materials and Design, 2021. DOI: 10.1016/j.matdes.2020.109277.
[57] VON WITZLEBEN Max, STOPPE Thomas, ZEINALOVA Alina, et al. Multimodal additive manufacturing of biomimetic tympanic membrane replacements with near tissue-like acousto-mechanical and biological properties[J]. Acta Biomaterialia, 2023, 170: 124-141.
[58] EICHHOLZ Kian F, PITACCO Pierluca, BURDIS Ross, et al. Integrating melt electrowriting and fused deposition modelling to fabricate hybrid scaffolds supportive of accelerated bone regeneration[J]. Advanced Healthcare Materials, 2024. DOI: 10.1002/adhm.202302057.
[59] BROOKS-RICHARDS Trent L, PAXTON Naomi C, ALLENBY Mark C, et al. Dissolvable 3D printed PVA moulds for melt electrowriting tubular scaffolds with patient-specific geometry[J]. Materials and Design, 2022. DOI: 10.1016/j.matdes.2022.110466.
[60] JUNGST Tomasz, PENNINGS Iris, SCHMITZ Michael, et al. Heterotypic scaffold design orchestrates primary cell organization and phenotypes in cocultured small diameter vascular grafts[J]. Advanced Functional Materials, 2019. DOI: 10.1002/adfm.201905987.
[61] BARTOLF-KOPP Michael, DE SILVA Leanne, ROSENBERG Antoine J W P, et al. Hybrid co-spinning and melt electrowriting approach enables fabrication of heterotypic tubular scaffolds resembling the non-linear mechanical properties of human blood vessels[J]. Advanced Functional Materials, 2024. DOI: 10.1002/adfm.202311797.
[62] LIAN Meifei, HAN Yu, SUN Binbin, et al. A multifunctional electrowritten bi-layered scaffold for guided bone regeneration[J]. Acta Biomaterialia, 2020, 118: 83-99.
[63] WANG Zixu, WANG Han, XIONG Junjie, et al. Fabrication and in vitro evaluation of PCL/gelatin hierarchical scaffolds based on melt electrospinning writing and solution electrospinning for bone regenera-tion[J]. Materials Science and Engineering: C, 2021. DOI: 10.1016/j.msec.2021.112287.
[64] GIRARD Fabien, LAJOYE Caroline, CAMMAN Marie, et al. First advanced bilayer scaffolds for tailored skin tissue engineering produced via electrospinning and melt electrowriting[J]. Advanced Functional Materials, 2024. DOI: 10.1002/adfm.202314757.
[65] GU Xiang, XU Yifan, LI Shuai, et al. Preparation of a photocured biocompatible hydrogel for urethral tissue engineering[J]. ACS Applied Polymer Materials, 2021, 3(7): 3519-3527.
[66] ROSS Maureen T, KILIAN David, LODE Anja, et al. Using melt-electrowritten microfibres for tailoring scaffold mechanics of 3D bioprinted chondrocyte-laden constructs[J]. Bioprinting, 2021. DOI: 10.1016/j.bprint.2021.e00158.
[67] MOO Eng Kuan, EBRAHIMI Mohammadhossein, HRYNEVICH Andrei, et al. Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2023. DOI: 10.1016/j.jmbbm.2023.105941.
[68] AFGHAH Ferdows, IYISON Necla Birgul, NADERNEZHAD Ali, et al. 3D fiber reinforced hydrogel scaffolds by melt electrowriting and gel casting as a hybrid design for wound healing[J]. Advanced Healthcare Materials, 2022. DOI: 10.1002/adhm.202102068.
[69] GRÖßBACHER Gabriel, BARTOLF-KOPP Michael, GERGELY Csaba, et al. Volumetric printing across melt electrowritten scaffolds fabricates multi-material living constructs with tunable architecture and mechanics[J]. Advanced Materials, 2023. DOI: 10.1002/adma.202300756.
[70] KONG Xiangkai, ZHU Delong, HU Ying, et al. Melt electrowriting (MEW)-PCL composite three-dimensional exosome hydrogel scaffold for wound healing[J]. Materials & Design, 2024. DOI: 10.1016/j.matdes.2024.112717.
[1] 李好义, 贾紫初, 刘宇亮, 谭晶, 丁玉梅, 杨卫民, 牟文英. 高压静电加载形式对聚合物熔体静电直写制备效果的影响[J]. 纺织学报, 2023, 44(04): 32-37.
[2] 顾力文, 阮艳雯, 李浩. 基于柔性选择性激光烧结3D打印技术的服装研发[J]. 纺织学报, 2023, 44(04): 154-164.
[3] 王曙东, 马倩, 王可, 谷元慧. 3D生物打印制备组织工程支架的研究进展[J]. 纺织学报, 2023, 44(03): 210-220.
[4] 李艾元, 施心雨, 岳万福, 游卫云. 丝素蛋白水凝胶支架的制备及其性能[J]. 纺织学报, 2022, 43(06): 44-48.
[5] 孙钰晟, 左保齐. 高分子聚合物硬骨缺损修复材料研究进展[J]. 纺织学报, 2021, 42(08): 175-184.
[6] 张蓓蕾, 沈明武, 史向阳. 静电纺短纤维的制备及其生物医学应用[J]. 纺织学报, 2021, 42(05): 1-8.
[7] 潘璐, 程亭亭, 徐岚. 聚己内酯/聚乙二醇大孔径纳米纤维膜的制备及其在组织工程支架中的应用[J]. 纺织学报, 2020, 41(09): 167-173.
[8] 贾琳 陈莉娜 张海霞 覃小红. 聚氨酯/胶原蛋白复合纳米纤维支架的性能[J]. 纺织学报, 2016, 37(08): 1-6.
[9] 王曙东;张幼珠;王红卫;尹桂波;董智慧;符伟国;施德兵. 静电纺PLA/丝素-明胶管状支架的结构与性能[J]. 纺织学报, 2009, 30(06): 6-9.
[10] 鲍扬波;王家俊;胡巧玲.. 聚合物静电纺及在组织工程支架中的应用[J]. 纺织学报, 2008, 29(2): 124-128.
[11] 高欣;张海萍;陈宇;朱良均;闵思佳. 丝素蛋白多孔材料及其在组织工程领域的应用[J]. 纺织学报, 2008, 29(10): 132-136.
Viewed
Full text
29

  From Others local
  Times 6 23
  Rate 21% 79%

Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
京ICP备14006648号　 京公网安备11010502044800号
版权所有 © 2021 《纺织学报》编辑部
地址： 北京市朝阳区延静里中街3号主楼6层《纺织学报》杂志社　邮政编码：100025　
电话：010-65017711,65917740　传真：010-65016539　Email:fangzhixuebao@vip.126.com
本系统由北京玛格泰克科技发展有限公司设计开发