Abstract: This paper uses regenerated keratin fiber/cotton blended yarn with different blending ratios for interweaving with polyester/cotton blended yarn,designs the cotton type mixture fabric of leisure style,and analyses the influence of regenerated keratin fiber content on the fabric style and wearing characteristics.Regression mode is established based on the relations between wearing characteristics of single item and blending ratio.Measured data indicates that a remarkable correlation exists between the regenerated keratin fiber content and abrasion resistance,crease recovery,draping,bending rigidity,air permeability of mixture fabric.The fabric with the blending ratio of the regenerated keratin fiber to cotton at about 60∶40 exhibits excellent performance in all items.The paper provides a theoretical basis for designing the regenerated keratin fiber mixture fabric.