Abstract: Wool fabrics` were finished with TG enzyme in order to decrease the damage of wool resulting from anti-felting treatment with protease. The remedy effect of TG enzyme to the damage of wool was studied. It was shown that TG enzyme can remedy the damage of wool caused by chemical pre-treatment and protease anti-felting finishing, increasing wool fabric strength and decreasing the alkali solubility. TG was capable of catalyzing covalent crosslinking of wool proteins. The optimum protease/TG anti-felting finishing conditions: dosage of protease, 1%（o.w.f.）; time, 30min; pH=8~9; dosage of TG, 2%（o.w.f）; time, 50min; pH=6~7; bath radio 20:1; and temperature, 50℃. The percentage area shrinkage of the wool fabric treated by this optimal process was 2.93%, the strength was 380.4N and the loss in strength was controled within 7.4%.