Abstract: 7 kinds of blended knitted fabrics with different blending ratioos of milk casein fiber, cotton and coolmax fibers were taken as research objectives with a view to investigating the wearability of milk casein fiber fabrics. The warm- retention property, water vapor permeability, air permeability, and hygroscopicity of the blended knitted fabrics were tested, and the thermal-moisture comfort of fabrics with different fiber contents was studied. By using the gray cluster analysis, the integrated evaluation of thermal-moisture comfort of the fabrics under different environmental conditions was conducted. The experimental results show that the fabrics containing milk casein fibers has better warm- retention and water vapor transmission properties. In summer, the thermal-moisture comfort of the blended fabric improves as the content of milk casein fibers increases. However, in winter, variation of the content of milk casein fibers has no significant effect on the fabric thermal-moisture comfort.