Abstract: Structure design is one of important factors that determines the comfort of protective clothing(PPC). By reviewing the research situation on PPC structure design both home and abroad and combining with research results, the paper investigated the influence of the garment structure design on clothing comfort from four aspects, that is, the interspaced air gaps，ventilation features，alternative construction designs，and construction design optimization of protective clothing system. The evaluation methods of PPC comfort were concluded. And the concept of concurrent engineering is proposed for applying to the development of protective clothing structure design.