Abstract: Silkworm silk and spider silk is favored by many researchers due to their excellent characteristics, and the researchers hope to obtain artificial silkworm silk or spider silk with good performance. But currently the available regenerated silkworm silk and spider silk is not satisfactory. This paper summarizes and compares the studies on regenerating silkworm and spider silk, including preparation of spinning solution, the wet-spinning and the electrospinning and the impact of the spinning conditions on properties, and explores the methods to improve the properties of the regenerated silk fibers, finally explains the bright future of the regenerated silk fiber, it is expected to provide useful information for the later studies on artificial silkworm silk and spider silk.