Abstract: Based on the heat-moisture transfer mechanism and heat-moisture comfort, a heat-moisture transfer mathematical model of plain knitted fabric is established and optimized with regression analysis method in order to illustrate the relationship between heat-moisture comfort and process parameters; With surface maps and contour maps,the main factors which affect heat-moisture comfort of plain knitted fabric are discussed.With unified objective function, a thermal comfort performance evaluation system is established.This study may provide important technical references for knitting enterprises to enhance the heat-moisture comfort of knitted fabrics.