Abstract: To prepare tissue engineering scaffolds, the the biocompatible PLGA and PLA are used as materials. The PLGA/PLA blended nanofibrous membrane is fabricated via electrospinning. The structure and properties of the PLGA/PLA blended nanofibers are characterized by means of SEM, rheometer, TG-DSC and tensile tester. The results show that the PLGA/PLA blended micro-nanofibers can be prepared successfully by electrospinning. The viscosity of the spinning solution increases with the increase of the blended ratio of PLA, which induces the increment of the diameters and leads the diameters distribute uniformity, and also results that the pose diameters increase and porosities decrease. The thermal analysis indicates that the crystallinity and stability of the PLGA/PLA blended nanofibers increase with the increase of the blended ratio of PLA. The breaking strength increases and the elongation decreases with the increase of the blended ratio of PLA. In order to meet the requests of different tissue engineering scaffolds, the blended ratio can be adjusted to control the structure and properties of the scaffolds.