转基因家蚕生产含蜘蛛丝蛋白的新型复合茧丝纤维

纺织学报 ›› 2012, Vol. 33 ›› Issue (5): 1-5.

• 纤维材料 • 下一篇

转基因家蚕生产含蜘蛛丝蛋白的新型复合茧丝纤维

张袁松^1，2,赵天福²,赵爱春²,文红秀²,中垣雅雄³

1. 西南大学纺织服装学院
2. 家蚕基因组生物学国家重点实验室（西南大学）
3. 日本信州大学纤维学部

收稿日期:2011-05-05 修回日期:2011-08-29 出版日期:2012-05-15 发布日期:2012-05-15
通讯作者: 张袁松 E-mail:yszhang@swu.edu.cn
基金资助:
中央高校基本科研业务费专项资金资助项目；教育部第39批留学基金项目；教育部春晖计划资助项目；人力资源和社会保障部留学人员科技活动优先资助基金项目；西南大学博士基金项目；

New silk fiber composite containing spider dragline silk protein and produced by transgenic silkworm

ZHANG Yuan-Song^1，2, ZHAO Tian-Fu², ZHAO Ai-Chun², WEN Hong-Xiu², ZHONG Yuan-Ya-Xiong³

1. College of Textiles & Garments, Southwest University
2. State Key Laboratory of Silkworm Genome Biology (Southwest university)
3. Faculty of Textile Science and Technology

Received:2011-05-05 Revised:2011-08-29 Online:2012-05-15 Published:2012-05-15
Contact: ZHANG Yuan-Song E-mail:yszhang@swu.edu.cn

摘要/Abstract

摘要： 蜘蛛丝是目前所知强度最高的天然蛋白质纤维，作为生物材料在工业、军事、医学等领域有很多用途，但是从自然界获得大量的蜘蛛丝是非常困难的。在本研究中，用piggyBac转基因载体将蜘蛛纵丝基因（MaSp1）导入家蚕染色体中，结果显示在稳定继代的第二代家蚕吐出的蚕茧中含有蜘蛛纵丝蛋白，获得了在蚕茧中稳定表达蜘蛛丝蛋白的转基因家蚕，该家蚕可以大量生产含有蜘蛛纵丝蛋白的复合茧丝新纤维。本研究表明利用转基因家蚕大量生产各种新型复合蛋白质纤维材料具有潜在的应用前景。

关键词: 转基因家蚕 , 蜘蛛丝 , 复合蚕丝

Abstract: Spider silk is an excellent fibre with combination of tensile strength and elasticity, but the isolation of large amount of spider silk in nature is difficult. Such superior biomaterials could be useful for industrial and medical purposes. In this study, We induce spider dragline silk (MaSp1) gene into the chromosome of silkworm by piggyBac transgenic vector. The result showed the trangeic silkworm can produce a new composite silk fiber that contains MaSp1 protein. It also suggested that produce many kinds of new composite protein fiber material by transgenic silkworm is feasible.

Key words: transgenic silkworm , spider silk , composite silk

张袁松, 赵天福, 赵爱春, 文红秀, 中垣雅雄. 转基因家蚕生产含蜘蛛丝蛋白的新型复合茧丝纤维[J]. 纺织学报, 2012, 33(5): 1-5.

ZHANG Yuan-Song, ZHAO Tian-Fu, ZHAO Ai-Chun, WEN Hong-Xiu, ZHONG Yuan-Ya-Xiong. New silk fiber composite containing spider dragline silk protein and produced by transgenic silkworm[J]. JOURNAL OF TEXTILE RESEARCH, 2012, 33(5): 1-5.

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转基因家蚕生产含蜘蛛丝蛋白的新型复合茧丝纤维

New silk fiber composite containing spider dragline silk protein and produced by transgenic silkworm

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