聚天冬氨酸基纤维水凝胶的制备及其释药性能

doi:10.13475/j.fzxb.20190403107

纺织学报 ›› 2020, Vol. 41 ›› Issue (02): 20-25.doi: 10.13475/j.fzxb.20190403107

聚天冬氨酸基纤维水凝胶的制备及其释药性能

李思捷, 张彩丹()

嘉兴学院材料与纺织工程学院, 浙江嘉兴 314000

收稿日期:2019-04-08 修回日期:2019-11-24 出版日期:2020-02-15 发布日期:2020-02-21
通讯作者: 张彩丹
作者简介:李思捷(2000—),女。主要研究方向为非织造材料的制备。
基金资助:
浙江省自然科学基金项目(LQ20E030014);嘉兴学院大学生创新训练项目(8517193245)

Preparation of poly(aspartic acid) based fiber hydrogel and its drug release behavior

LI Sijie, ZHANG Caidan()

College of Material and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang 314000, China

Received:2019-04-08 Revised:2019-11-24 Online:2020-02-15 Published:2020-02-21
Contact: ZHANG Caidan

摘要/Abstract

摘要：

为开发具有pH值敏感性的药物缓释体系,以pH值敏感型材料聚天冬氨酸(PASP)的中间体聚琥珀酰亚胺(PSI)和热塑性聚氨酯(TPU)为纺丝原料,以5-氟尿嘧啶为药物模型,采用同轴静电纺丝法制备皮芯结构PSI/TPU纤维膜,通过后处理制得PASP/TPU纤维水凝胶载药体系。探究纺丝参数、后处理工艺对纤维膜形貌结构、化学结构、力学性能和溶胀性能的影响,并分析了药物体外释放行为。结果表明:PSI/TPU纤维膜经交联、水解反应可形成PASP/TPU纤维水凝胶,随着同轴纺丝过程中内层TPU流速的增加,PASP/TPU纤维水凝胶的芯层变厚,力学性能增加,溶胀性能变差;PASP/TPU纤维水凝胶具有pH值敏感性,溶胀倍率随pH值升高而增加;PASP/TPU纤维水凝胶的药物体外释放速率随缓释介质pH值的不同而发生变化。

关键词: pH值敏感型材料, 纤维水凝胶, 同轴静电纺丝, 聚天冬氨酸, 药物缓释

Abstract:

To develop a sustained drug delivery system with pH sensitivity, polysuccinimide (PSI), as the intermediate of pH-sensitive polyaspartic acid (PASP), and thermoplastic polyurethane (TPU) were used to produce electro-spun membranes, with 5-fluorouracil being the model drug. The PSI/TPU fiber membrane with skin-core structure was prepared by coaxial electrospinning. Then PASP/TPU fiber hydrogel based drug-loading system was obtained by post-treatment of PSI/TPU fiber membrane. The effects of electro-spinning parameters and post-treatment on fiber membrane morphology, chemical structure, mechanical properties and swelling properties were analyzed. The drug release behavior of PASP/TPU fiber hydrogel in vitro was studied. The results show that PASP/TPU fiber hydrogel is gained by crosslinking and hydrolysis of PSI/TPU fiber membrane. With the increase of inner layer flow rate during coaxial electrospinning, the core thickness and mechanical properties of PASP/TPU fiber hydrogel increase, while the swelling ratio of PASP/TPU fiber hydrogel decreases. In addition, PASP/TPU fiber hydrogel with pH sensitivity exhibits swelling ratio increase when increasing the pH value. Drug release rate of PASP/TPU nanofiber hydrogel in vitro varies according to the pH value of release medium.

Key words: pH sensitivity material, fiber hydrogel, coaxial electrospinning, polyaspartic acid, sustained drug delivery

中图分类号:

TS101.4

李思捷, 张彩丹. 聚天冬氨酸基纤维水凝胶的制备及其释药性能[J]. 纺织学报, 2020, 41(02): 20-25.

LI Sijie, ZHANG Caidan. Preparation of poly(aspartic acid) based fiber hydrogel and its drug release behavior[J]. Journal of Textile Research, 2020, 41(02): 20-25.

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聚天冬氨酸基纤维水凝胶的制备及其释药性能

Preparation of poly(aspartic acid) based fiber hydrogel and its drug release behavior

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