纺织学报 ›› 2020, Vol. 41 ›› Issue (07): 15-22.doi: 10.13475/j.fzxb.20191000408

• 纤维材料 • 上一篇    下一篇

纤维基介孔SiO2药物载体的构建及其释药性能

段红梅, 汪希铭, 黄子欣, 高晶(), 王璐   

  1. 东华大学 纺织学院, 上海 201620
  • 收稿日期:2019-10-08 修回日期:2020-01-20 出版日期:2020-07-15 发布日期:2020-07-23
  • 通讯作者: 高晶
  • 作者简介:段红梅(1994—),女,硕士生。主要研究方向为纺织生物材料。
  • 基金资助:
    国家卫生计生委重大疾病防治科技行动计划专项(2017ZX01001-S22)

Construction and drug release properties of fiber-based mesoporous SiO2 drug carrier

DUAN Hongmei, WANG Ximing, HUANG Zixin, GAO Jing(), WANG Lu   

  1. College of Textiles, Donghua University, Shanghai 201620, China
  • Received:2019-10-08 Revised:2020-01-20 Online:2020-07-15 Published:2020-07-23
  • Contact: GAO Jing

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摘要：

为研究纤维基载药介孔SiO2纳米粒子的释药性能,采用溶胶-凝胶法制备介孔SiO2,并采用静电纺丝技术制备了负载介孔SiO2的聚己内酯(PCL)纤维膜,在介孔SiO2纳米粒子中装载抗菌药物盐酸环丙沙星,于酸性条件下分别探讨了盐酸环丙沙星在纳米粒子和复合纤维膜中的释放性能及释放机制,并对2种药物释放模型进行动力学研究。结果表明:介孔SiO2纳米粒子的成型受pH值影响较大,在可成型范围内,随着pH值的增大,纳米粒子的粒径逐渐增大;随着介孔SiO2比例的增加,PCL复合纤维的细度逐渐下降;盐酸环丙沙星在单独纳米粒子和复合纤维膜中的释放都具有初始释放速率大,后期释放缓慢的特点,12 h内在2种载体中的累积释放率分别可达到55.51%和16.53%;扩散是药物在2种载体中释放的主要机制。

关键词: 介孔二氧化硅, 纳米纤维膜, 盐酸环丙沙星, 载药, 药物释放

Abstract:

In order to study the drug releasing performance of fiber-based mesoporous SiO2, mesoporous SiO2 nanoparticles was prepared using sol-gel method, and the polycaprolactone (PCL) fiber membranes loaded with mesoporous SiO2 nanoparticles were prepared by electrospinning. The antibacterial drug ciprofloxacin hydrochloride was loaded into mesoporous SiO2 nanoparticles, and the releasing properties and releasing mechanism of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes were investigated under acidic conditions. The results show that the formation of mesoporous SiO2 nanoparticles is greatly affected by pH value. Within the moldable range, the particle size of the nanoparticles increases with increasing pH value. As the proportion of mesoporous SiO2 nanoparticles increases, the fineness of PCL composite fibers gradually decreases. The release of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes has a large initial release rate and a slow release in the later stage, the cumulative release rate in the two carriers within 12 h reaches 55.51% and 16.53%, respectively. The results of kinetic studies on the two drug release models indicate that diffusion is the main mechanism of drug release.

Key words: mesoporous silica, nanofiber membrane, ciprofloxacin hydrochloride, drug loading, drug release

中图分类号: 

  • TS101.4

图1

不同pH值条件下反应得到的MSNs的TEM照片"

图2

MSNs在550 ℃焙烧前后的红外光谱图"

图3

MSNs的小角X射线衍射图"

图4

MSNs的氮气吸脱附等温线和孔径分布图"

图5

Cip在水溶液和pH=5.4的PBS缓冲液中的标准曲线"

图6

药物溶液质量浓度对MSNs包封率和载药量的影响"

图7

不同MSNs质量分数Cip-MSNs/PCL复合纤维膜的SEM照片"

图8

Cip-MSNs/PCL复合纤维膜的EDX图谱"

图9

不同药物载体中Cip的释放曲线"

图10

不同载体中药物Cip释放动力学模型拟合"

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