含银海藻酸盐医用敷料的临床应用

doi:10.13475/j.fzxb.20191205108

摘要/Abstract

摘要：

为促进含银海藻酸盐纤维在医疗卫生领域的应用,开发具有高吸湿、强抗菌性的功能性医用敷料,介绍了国际市场上含银海藻酸盐纤维和医用敷料的主要品种、制备方法、产品性能及其应用领域;总结了含银海藻酸盐纤维和医用敷料在慢性伤口护理中控制创面感染增加细菌转阴率、抑制细菌增长减轻患者疼痛、促进伤口愈合缩短治疗周期以及降低治疗费用等方面的优良使用功效;总结了合理使用含银医用敷料过程中需要考虑的因素。结合全球各地的最新临床应用研究成果指出:含银海藻酸盐医用敷料在感染伤口、烧伤创面、手术切口、糖尿病足溃疡伤口、下肢静脉溃疡、压疮等创面护理中的应用价值。

关键词: 海藻酸盐纤维, 医用敷料, 生物医用材料, 银离子, 抗菌性能

Abstract:

In order to promote the applications of silver containing alginate fibers and develop functional wound dressings with high absorbency and strong antimicrobial properties, this paper introduced the main varieties, production methods, product properties and applications of silver containing fibers and wound dressings in the international market, and summarized their efficacy in reducing the re-infection ratio through control of wound infection, relieving pain through suppression of bacteria growth, shortening treatment cycle through the promotion of healing and reducing the treatment cost and other outstanding benefits. Combining the latest clinical research results from around the world, this paper outlined the clinical values of silver containing alginate fibers and wound dressings in the management of infected wound, burn wound, clinical incision, diabetic foot ulcer, leg ulcer, pressure sore and other types of wounds.

Key words: alginate fiber, wound dressing, biomedical material, silver ion, antimicrobial property

中图分类号:

TS131.9

秦益民. 含银海藻酸盐医用敷料的临床应用[J]. 纺织学报, 2020, 41(09): 183-190.

QIN Yimin. Clinical applications of silver containing alginate wound dressings[J]. Journal of Textile Research, 2020, 41(09): 183-190.

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产品名称	制造商	基础材料	银化合物
Acticoat Absorbent	Smith & Nephew	海藻酸盐纤维复合聚乙烯膜	纳米银
Algicell Ag	Derma Sciences	海藻酸钙纤维	银离子
Algidex Ag	DeRoyal	海藻酸钙纤维复合泡绵	银离子
Algisite Ag	Smith & Nephew	海藻酸钙纤维	银离子
Askina Calgitrol Ag	B. Braun	海藻酸钙纤维复合泡绵	银离子
Invacare Silver Alginate	Invacare	海藻酸盐与CMC共混纤维	磷酸锆钠银
Maxorb Extra Ag	Medline	海藻酸盐与CMC共混纤维	磷酸锆钠银
Melgisorb Ag	M?lnlycke	海藻酸盐与CMC共混纤维	磷酸锆钠银
Restore Calcium Alginate	Hollister Woundcare	海藻酸钙纤维	银离子
SeaSorb Ag	Coloplast	海藻酸盐与CMC共混纤维	磷酸锆钠银
Silvercel & Silvercel Non Adherent	Systagenix	海藻酸盐与CMC共混纤维复合不粘层	镀银锦纶纤维
Silverlon Calcium Alginate	Argentum Medical	海藻酸钙纤维	镀银锦纶纤维核心层
Tegaderm Alginate Ag	3 M	海藻酸盐与CMC共混纤维	磷酸锆钠银
UrgoSorb Silver	Urgo	海藻酸盐与CMC共混纤维	磷酸锆钠银

组别	例数	伤口细菌转阴例数
组别	例数	治疗7 d后	治疗14 d后	治疗21 d后
观察组	62	19	28	56
对照组	62	11	20	39

组别	疼痛评分
组别	换药前	换药后3 d	换药后7 d	换药后15 d
观察组	5.47±1.22	3.08±0.54	2.66±0.53	1.96±0.41
对照组	5.89±1.54	5.53±0.68	4.88±0.75	2.12±0.72

组别	例数	换药时间/d	创面愈合时间/d
观察组	40	7.69±2.19	10.57±4.38
对照组	40	13.57±3.48	17.58±4.50

组别	肉芽覆盖时间/d	肉芽痊愈时间/d	愈合时间/d
观察组	3.75±1.20	6.28±1.39	11.70±2.24
对照组	6.85±2.04	8.39±1.54	14.57±3.86