聚乳酸纳米纤维基载药敷料的制备与表征

doi:10.13475/j.fzxb.20210908508

纺织学报 ›› 2022, Vol. 43 ›› Issue (11): 1-8.doi: 10.13475/j.fzxb.20210908508

• 纤维材料 • 下一篇

聚乳酸纳米纤维基载药敷料的制备与表征

李亮¹, 裴斐斐², 刘淑萍³, 田苏杰⁴, 许梦媛³, 刘让同³(), 海军¹

1.中原工学院纺织学院, 河南郑州 451191
2.郑州大学第一附属医院, 河南郑州 450052
3.中原工学院服装学院, 河南郑州 451191
4.江南大学纺织科学与工程学院, 江苏无锡 214122

收稿日期:2021-09-22 修回日期:2022-03-17 出版日期:2022-11-15 发布日期:2022-12-26
通讯作者: 刘让同
作者简介:李亮(1983—),男,讲师,硕士。主要研究方向为新型纺织材料与纺织品整理技术。
基金资助:
国家重点研发计划项目(2017YFB0309100)

Preparation and characterization of polylactic acid nanofiber drug loaded medical dressings

LI Liang¹, PEI Feifei², LIU Shuping³, TIAN Sujie⁴, XU Mengyuan³, LIU Rangtong³(), HAI Jun¹

1. Textile College, Zhongyuan University of Technology, Zhengzhou, Henan 451191, China
2. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
3. Fashion Technology College, Zhongyuan University of Technology, Zhengzhou, Henan 451191, China
4. College of Textile Science and Engineering, Jiangnan University,Wuxi, Jiangsu 214122, China

Received:2021-09-22 Revised:2022-03-17 Published:2022-11-15 Online:2022-12-26
Contact: LIU Rangtong

摘要/Abstract

摘要：

为构筑可自降解、抗菌消炎且轻薄柔软有助于伤口愈合的医用敷料,以聚乳酸为原料,通过掺杂不同质量分数的阿莫西林,采用静电纺丝技术制备聚乳酸纳米纤维基载药敷料。借助扫描电子显微镜、红外光谱仪、X射线衍射仪、接触角测试仪、紫外分光光度计等手段分析纳米纤维膜的微观结构、润湿性能、药物缓释、抗菌性能以及自降解性能。结果表明:聚乳酸纳米纤维敷料具有多孔结构,敷料纤维直径随载药量增加而降低,敷料载药量3%时,纤维平均直径达684 nm;载药聚乳酸纳米纤维基敷料中阿莫西林与聚乳酸没有发生化学反应,避免了阿莫西林的负面改性;聚乳酸纳米纤维基载药敷料润湿性与抗菌性能随载药量增加而增加,载药3%敷料的接触角降到110°,提高了润湿性,对金黄色葡萄球菌的抑菌率可达91%。聚乳酸纳米纤维载药敷料具有较好的自降解性能和平缓的药物缓释能力,适合用作伤口敷料。

关键词: 聚乳酸, 纳米纤维, 医用敷料, 抗菌性能, 缓释性

Abstract:

In order to construct a self-degradable, antibacterial, anti-inflammatory, light, thin and soft medical dressings conducive to wound healing, nanofiber drug loaded dressings based on polylactic acid (PLA) was prepared by electrospinning technology with different mass fractions of amoxicillin. The microstructure, wettability, drug release, antibacterial and self-degradation properties of nanofiber films were analyzed by means of scanning electron microscope, infrared spectrometer, X-ray diffraction, contact angle tester and UV spectrophotometer. The results indicate that the PLA nanofiber dressings possess porous structure and the diameter of dressing fiber decreases with the increase of drug loading. When the drug loading is 3%, the average diameter of dressing fiber is 684 nm. There is no chemical reaction between amoxicillin and polylactic acid, suggesting that negative modification did not occur for the amoxicillin. Moreover, the wettability and antibacterial properties of drug loaded PLA nanofiber dressings are enhanced with the increase of drug loading. The antibacterial rate of nanofiber dressings with 3% drug loading is up to 91% for staphylococcus aureus. In addition, polylactic acid nanofiber dressings represent excellent in-vitro degradation performance, drug release ability and stable release rate, which are necessary for wound dressings.

Key words: polyalctic acid, nanofiber, medical dressings, antibacterial, drug sustained release

中图分类号:

TS174.8

李亮, 裴斐斐, 刘淑萍, 田苏杰, 许梦媛, 刘让同, 海军. 聚乳酸纳米纤维基载药敷料的制备与表征[J]. 纺织学报, 2022, 43(11): 1-8.

LI Liang, PEI Feifei, LIU Shuping, TIAN Sujie, XU Mengyuan, LIU Rangtong, HAI Jun. Preparation and characterization of polylactic acid nanofiber drug loaded medical dressings[J]. Journal of Textile Research, 2022, 43(11): 1-8.

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载药量/%	黏度/(mPa·s)	电导率/(μS·cm^-1)
0	74.2	1.56
1	69.4	1.97
2	66.8	2.52
3	67.1	2.84

聚乳酸纳米纤维基载药敷料的制备与表征

Preparation and characterization of polylactic acid nanofiber drug loaded medical dressings

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