粘胶织物中烟酰胺的释放曲线及其模型拟合

doi:10.13475/j.fzxb.20210911508

纺织学报 ›› 2023, Vol. 44 ›› Issue (03): 139-146.doi: 10.13475/j.fzxb.20210911508

粘胶织物中烟酰胺的释放曲线及其模型拟合

朱维维¹^,², 龙家杰¹^,², 施楣梧¹^,²^,³()

1.苏州大学纺织与服装工程学院, 江苏苏州 215123
2.超临界流体无水绳状匹染技术科研基地(中国纺织工程学会), 江苏苏州 215123
3.北京海淀第57离职干部休养所, 北京 100035

收稿日期:2021-09-28 修回日期:2022-10-22 出版日期:2023-03-15 发布日期:2023-04-14
通讯作者: 施楣梧(1957—),男,教授级高工,博士。主要研究方向为电磁纺织品、阻燃材料及其它功能性纤维材料的开发。E-mail:shimeiwu@263.net.cn。
作者简介:朱维维(1989—),女,博士。主要研究方向为基于超临界CO₂流体的功能性纺织品开发。

Release curve of nicotinamide from viscose fabrics and its model fitting

ZHU Weiwei¹^,², LONG Jiajie¹^,², SHI Meiwu¹^,²^,³()

1. College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215123, China
2. Scientific Research Base for Waterless Coloration with Supercritical Fluid (China Textile Engineering Society), Suzhou, Jiangsu 215123, China
3. Beijing Haidian No. 57 Retired Cadres Rest House, Beijing 100035, China

Received:2021-09-28 Revised:2022-10-22 Published:2023-03-15 Online:2023-04-14

摘要/Abstract

摘要：

为将新兴的绿色、高效的超临界CO₂流体整理技术用于生物活性纺织品开发,提高服用类织物附加值,以生物活性药物烟酰胺为模型药物,粘胶织物为基材,利用超临界CO₂流体分别在不同温度、压力条件下制备负载有烟酰胺的生物活性粘胶织物,将其置于释放介质中,考察烟酰胺从粘胶织物中释放行为的影响因素。结果表明:烟酰胺从粘胶织物中的绝对释放量及绝对释放速率与其在粘胶织物上的负载量正相关;低流体温度(60 ℃)以及高流体压力(20 MPa)下制备的生物活性粘胶织物累积释放百分比及累积释放速率更低,释放平衡时分别接近87.6%、87.3%;烟酰胺从粘胶织物中的释放行为符合Korsmeyer-Peppas模型,其扩散以菲克扩散为主。

关键词: 超临界CO₂流体, 烟酰胺, 粘胶织物, 绝对释放量, 绝对释放速率, 生物活性纺织品, 释放行为

Abstract:

Objective Supercritical carbon dioxide fluid (SCF-CO₂) is a new green processing and high-efficiency finishing technology, nontoxic, nonflammable and can be recycled, which have been used to impregnate the drug into polymer matrix in biomedical field widely and is superior to the traditional finishing technology. In order to fabricate bioactive textile with good bioactive drug release property through SCF-CO₂impregnation processfor increasing the added value of clothing fabrics, it is necessary to analysis the variation and influence factors of release property of drug from bioactive textile fabricated by SCF-CO₂.

Method The bioactive drug nicotinamide with skin whitening, nourishing was used as the model drug, and viscose fabric was used as the substrate. Nicotinamide-loaded bioactive viscose fabrics processed by SCF-CO₂ under different temperatures (60, 70 and 80 ℃) and different pressures(12, 16 and 20 MPa), which were placed in the same release medium and measured the drug release amount in specific time by ultraviolet spectrophotometer. Ethanol was regarded as the release medium. Finally, the release curves that the drug release amount varied with time were drawn. The drug loading capacity was also measured. Besides, the release curves were fitted by different release models.

Results A higher absolute release quantity and a higher absolute release rate are obtained respectively when the supercritical CO₂(SCCO₂)temperature is 80 ℃, compared to 60, 70 ℃ of SCCO₂ temperature. Besides, the drug loading capacity increases with increasing SCCO₂temperature and the values are 6.165 4, 6.617 2 and 8.936 7 mg/g per weight of raw viscose fabric respectively. A higher absolute release quantity and a higher absolute release rate are also obtained respectively when the pressures are above 16 MPa as illustrated, compared to 12 MPa of SCCO₂ pressure. The drug loading capacity also increases with increasing pressure and the values are 0.838 7, 4.955 3 and 6.617 2 mg/g per weight of raw viscose fabric respectively. A lower cumulative release percentage and a lower cumulative release rate are obtained respectively when the SCCO₂ temperature is 60 ℃, which have an increasing tendency with increasing SCCO₂ temperature, and the cumulative release percentage can be as low as 87.6% when it reaches the releasing equilibrium. On the contrary, a lower cumulative release percentage and a lower cumulative release rate are obtained respectively when the SCCO₂ pressure is 20 MPa, which have a decreasing tendency with increasing SCCO₂ pressure, and the cumulative release percentage can be as low as 87.3% when it reaches the releasing equilibrium. The R² of Korsmeyer-Peppas model for all the release curves of nicotinamide-loaded viscose fabric processed by different SCCO₂ temperature, pressure is much higher than Zero-order release model, Higuchi model, and the R²is above 0.935 39 as depicted in Tab.1 and 2. Moreover, the corresponding diffusion index is generally below 0.45 except that the one processed under 60 ℃ of SCCO₂ temperature.

Conclusion The absolute release quantity and release rate of nicotinamide from viscose fabric are positively related to its loading capacity on the viscose fabric that vary with different SCCO₂ temperature and pressure. A higher loading capacity results in a higher absolute release quantity and a higher release rate. A lower cumulative release percentage and a lower cumulative release rate can be obtained when nicotinamide-loaded bioactive viscose fabric is processed by a lower SCCO₂ temperature or a higher SCCO₂ pressure. It means the cumulative release property is correlated to the density of SCCO₂. The release kinetics of nicotinamide-loaded viscose fabric processed by SCCO₂ are more consistent with Korsmeyer-Peppas model. Moreover, the diffusion behavior of nicotinamide from viscose fabric is mainly belong to Fick diffusion.

Key words: supercritical carbon dioxide fluid, nicotinamide, viscose fabric, absolute release quantity, absolute release rate, bioactive textile, elease behavior

中图分类号:

TS195

朱维维, 龙家杰, 施楣梧. 粘胶织物中烟酰胺的释放曲线及其模型拟合[J]. 纺织学报, 2023, 44(03): 139-146.

ZHU Weiwei, LONG Jiajie, SHI Meiwu. Release curve of nicotinamide from viscose fabrics and its model fitting[J]. Journal of Textile Research, 2023, 44(03): 139-146.

图/表 6

图1

图2

表1

不同流体温度制备的生物活性粘胶织物各模型拟合参数"

流体温度/℃	模型	模型方程	R²
60	零级释放模型	$Q t = (0.39114 t + 23.59073$ )×100%	0.783 56
	Higuchi模型	$Q t = (6.75903 t 0.5 + 1.45776$ )×100%	0.931 29
	Korsmeyer-Peppas模型	$Q t = (8.51122 t 0.45586$ )×100%	0.935 35
70	零级释放模型	$Q t = (0.26811 t + 46.5634$ )×100%	0.503 19
	Higuchi模型	$Q t = (5.18487 t 0.5 + 27.03036$ )×100%	0.781 75
	Korsmeyer-Peppas模型	$Q t = (32.57524 t 0.19643$ )×100%	0.984 88
80	零级释放模型	$Q t = (0.33163 t + 43.64796$ )×100%	0.571 20
	Higuchi模型	$Q t = (6.25345 t 0.5 + 20.75018$ )×100%	0.832 89
	Korsmeyer-Peppas模型	$Q t = (24.95905 t 0.2661$ )×100%	0.943 07

表1

图3

图4

表2

不同流体压力制备的生物活性粘胶织物各模型拟合参数"

流体压力/MPa	模型	方程	R²
12	零级释放模型	$Q t = (0.21058 t + 66.23545$ )×100%	0.229 07
	Higuchi模型	$Q t = (4.54857 t 0.5 + 47.12954$ )×100%	0.500 12
	Korsmeyer-Peppas模型	$Q t = (66.15522 t 0.07598$ )×100%	0.998 41
16	零级释放模型	$Q t = (0.2616 t + 52.81256$ )×100%	0.433 72
	Higuchi模型	$Q t = (5.18591 t 0.5 + 32.75056$ )×100%	0.719 83
	Korsmeyer-Peppas模型	$Q t = (40.57053 t 0.16384$ )×100%	0.988 30
20	零级释放模型	$Q t = (0.26811 t + 46.5634$ )×100%	0.503 19
	Higuchi模型	$Q t = (5.18487 t 0.5 + 27.03036$ )×100%	0.781 75
	Korsmeyer-Peppas模型	$Q t = (32.57524 t 0.19643$ )×100%	0.984 88

表2

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粘胶织物中烟酰胺的释放曲线及其模型拟合

Release curve of nicotinamide from viscose fabrics and its model fitting

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