Abstract: The development of electrospinning was reviewed;the principle of electrospinning was introduced;the conventional electerospinning setup for producing randomly oriented fibers,the new setups for preparing aligned electrospun fibers,and the co-axial electrospinning fabricating nanofibers with core-shell structures were presented;the influencing factors including the viscosity,surface tension,and the density of net charges carried by the jet on morphology of electrospun fibers were discussed;the application studies of polymeric fibrous scaffolds prepared by electrospinning for tissue engineering including skin,cartilage,blood vessel,and neural tissues were enumerated.