Abstract: In the field of clothing thermal-wet comfort studying, this paper is proposed that "Fiber - Yarn - Fabrics - Clothing" can be made as the research system for the first time. With studying of clothing thermal-wet comfort, this paper chooses the knitting fabric to be the object of study. The research focuses on the relationship between the performances of knitting fabric and clothing comfort. Based on this, after testing of basic performance, style, comfort and clothing comfort, according to the experiments, it analysis that these three variables— “fibers”, “yarn properties” and “fabric performance”— influence clothing thermal-wet comfort. By methods of math-statistics, it is set up a prediction model of clothing thermal-wet comfort.