Abstract:

To fabricate alginate-based fibrous dressings for wound healing, the alginate-silica and alginate-hydroxyapatite composite fibrous dressings were fabricated by blending nano-silica/hydroxyapatite with alginate as core flow and calcium chloride water solution as cortical flow by microfluidic spinning. The characterization of biotoxicity, in vitro biomineralization and degradation behavior, mechanical performances were carried out. Results demonstrate that the incorporation of silica particle in alginate fibers exhibited the mineral deposition in the process of degradagion and porosity  struture appears on the surface benificial for nutrient transportation and tissue regeneration. The prompt proliferation of fibroblast and keratinocytes cells indecate no significant cytotoxicity of prepared dressings. Furthermore, the reinforced composite alginate fibrous dressings containing silica and hydroxyapatite particle decreases the degradation degree by about 20% and increases the breaking stress by about 18%, compared with the pure alginate fibers.

Key words: alginate, silica, hydroxyapatite, fibrous dressings, microfluidic spinning