Journal of Textile Research ›› 2019, Vol. 40 ›› Issue (02): 20-25.doi: 10.13475/j.fzxb.20181006406

• Fiber Materials • Previous Articles     Next Articles

Application of UV-Vis spectrophotometry in quantitative monitoring sustained release of 2,3,5-triiodobenzoic acid

LIU Laijun1,2, XU Haiyan1,2, ZHAO Fan1,2, WANG Fujun1,2(), WANG Lu1,2   

  1. 1. College of Textiles, Donghua University, Shanghai 201620, China
    2. Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai 201620,China
  • Received:2018-10-31 Revised:2018-11-16 Online:2019-02-15 Published:2019-02-01
  • Contact: WANG Fujun E-mail:wfj@dhu.edu.cn

RichHTML

6

PDF (PC)

79

Abstract:

In order to study the sustained release rules of 2,3,5-triiodobenzoic acid (TIBA) in degradation solution of radiopaque poly-p-dioxanone (PPDO) filaments, the UV spectrums and regression curves of TIBA in different volume ratio blend degradation solutions of phosphate buffered saline (PBS) and ethanol (VPBS:Vethanol were 1:3,1:1 and 3:1) were explored by UV-Vis Spectrophotometry. According to regression curve, the release amount of TIBA in the degradation period was measured and calculated and then fitted with a drug release models and the corresponding release rules were analyzed. The results show that ideal spectrums and regression curves could be obtained in three kinds of blend solution. Considering the amount of ethanol used, the volume ratio of 3:1 was selected as the standard solution and it can still maintain stability after placing in an environment of 37 ℃ for 8 d. The results of model fit show that the release rule of TIBA is in consistence with the first-order release model.

Key words: ultraviolet-visible spectrophotometry, developing fiber, fiber degradation, 2,3,5-triiodobenzoic acid, release models

CLC Number: 

  • TS101

Fig.1

Schematic diagram of degradation fluid collection process"

Fig.2

Spectrum (a) and regression analysis (b) of TIBA in solution R1"

Fig.3

Spectrum(a) and regression analysis(b) of TIBA in solution R2"

Fig.4

Spectrum(a) and regression analysis(b) of TIBA in solution R3"

Fig.5

Spectrum (a) and regression analysis(b) of TIBA in solution R3 after 8 days"

Tab.1

Common drug release kinetics"

释放模型 函数模型 释放机制
零级释放 Mt/M0=kt 恒速释放
一级释放 ln(1-Mt/ M0)=-kt 一级释放
Peppas-Korsmeyer方程 Mt/M0=ktn 扩散和溶蚀
Higuchi方程 Mt/M0=kt1/2 Fick扩散

Fig.6

Cumulative release ratio of TIBA in S1、S2 and S3"

Tab.2

TIBA release fitting parameters in S1、S2 and S3"

释放模型 释放动力学系数k R2
S1 S2 S3 S1 S2 S3
零级释放 0.044 9 0.043 3 0.044 7 0.687 0.837 0.802
一级释放 0.506 2 0.168 1 0.216 0 0.958 0.985 0.995
Peppas-Korsmeyer方程 0.588 1 0.316 0 0.362 9 0.925 0.958 0.925
Higuchi方程 0.226 3 0.208 3 0.217 3 0.432 0.912 0.848

Fig.7

Cumulative release rate-time fitting results of TIBA in S2"

[1] QIU Z C, ZHANG J J, HUANG C L, et al. The influence of the surface character of the clays on the properties of poly(p-dioxanone)/fibrous clay nanocomposites[J]. Journal of Applied Polymer Science, 2012,125:247-259.
[2] ZHAO F, XUE W, WANG F J, et al. A new approach to improve the local compressive properties of PPDO self-expandable stent[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2017,68:318-326.
doi: 10.1016/j.jmbbm.2017.02.015 pmid: 28237687
[3] ZHAO Y Q, DING S D, YUAN Y, et al. Enhanced degradation stability of poly(p-dioxanone) under different temperature and humidity with bis-(2,6-diisopropylphenyl) carbodiimide[J]. Journal of Applied Polymer Science, 2014,131(6):596-602.
[4] 李利发, 张井潇, 陈小波, 等. 三种不同缝合线对腹壁手术切口愈合质量影响的研究[J]. 中国普外基础与临床杂志, 2016,23(4):445-449.
LI Lifa, ZHANG Jingxiao, CHEN Xiaobo, et al. Study on the effect of three kinds of different suture on the healing quality of abdominal incision[J]. Chinese Journal of Bases and Clinics in General Surgery, 2016,23(4):445-449.
[5] ZHAO F, XUE W, WANG F J, et al. Composite self-expanding bioresorbable prototype stents with reinforced compression performance for congenital heart disease application: computational and experimental investigation[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2018,84:126-134.
doi: 10.1016/j.jmbbm.2018.05.009 pmid: 29775814
[6] TANG H, XU Z, QIN X, et al. Chest wall reconstruction in a canine model using polydioxanone mesh, demineralized bone matrix and bone marrow stromal cells[J]. Biomaterials, 2009,30(19):3224-3233.
doi: 10.1016/j.biomaterials.2009.02.007 pmid: 19233465
[7] SINGHANA B, CHEN A, SLATTERY P, et al. Infusion of iodine-based contrast agents into poly(p-dioxanone) as a radiopaque resorbable IVC filter[J]. Journal of Materials Science: Materials in Medicine, 2015,26(3):124.
pmid: 25690619
[8] 曲乐, 曹江, 黄新苗. 可降解聚对二氧环己酮材料的临床应用[J]. 中国组织工程研究与临床康复, 2011,15(3):527-530.
QU Le, CAO Jiang, HUANG Xinmiao. Clinical application of biodegradable polydioxanone[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011,15(3):527-530.
[9] SERIO P, FAINARDI V, LEONE R, et al. Tracheobronchial obstruction: follow-up study of 100 children treated with airway stenting[J]. European Journal of Cardio-Thoracic Surgery, 2014,45(4):100-109.
doi: 10.1093/ejcts/ezt284
[10] LEON C M, LEE B H, PREUL M, et al. Synjournal and characterization of radio-opaque thermosensitive poly N-isopropylacrylamide-2,2'-(ethylenedioxy)bis(ethylamine)-2,3,5-triiodobenzamide[J]. Polymer International, 2009,58(8):847-850.
doi: 10.1002/pi.2616
[11] STURZU A, VOGEL U, GHARABAGHI A, et al. Cell nucleus directed 2,3,5-triiodobenzoic acid conju-gates[J]. Medicinal Chemistry, 2009,5(4):385-391.
pmid: 19689397
[12] MARTYNENKO A, CHEN Y. Degradation kinetics of total anthocyanins and formation of polymeric color in blueberry hydrothermodynamic (HTD) processing[J]. Journal of Food Engineering, 2016,171(4):44-51.
doi: 10.1016/j.jfoodeng.2015.10.008
[13] 陈力, 刘砚韬, 黄亮, 等. 缓控释系统药物释放的数学模型研究进展[J]. 中国药业, 2008,17(11):1-4.
CHEN Li, LIU Yantao, HUANG Liang, et al. Research progress of mathematic model of sustained and controlled release system of drug release[J]. China Pharmaceuticals, 2008,17(11):1-4.
[14] TABANDEH H, MORTAZAVI S A. An investigation into the drug release from ibuprofen matrix tablets with ethylcellulose and some poly-acrylate polymers[J]. Pakistan Journal of Pharmaceutical Sciences, 2014,27(3):495-503.
pmid: 24811808
[15] KAFFASHI B, DAVOODI S, OLIAEI E. Poly(epsilon-caprolactone)/triclosan loaded polylactic acid nanoparticles composite: a long-term antibacterial bionanocomposite with sustained release[J]. International Journal of Pharmaceutics, 2016,508(1/2):10-21.
doi: 10.1016/j.ijpharm.2016.05.009
[16] KARAMI Z, REZAEIAN I, ZAHEDI P, et al. Preparation and performance evaluations of electrospun poly(epsilon-caprolactone), poly(lactic acid), and their hybrid (50/50) nanofibrous mats containing thymol as an herbal drug for effective wound healing[J]. Journal of Applied Polymer Science, 2013,129(2):756-766.
doi: 10.1002/app.38683
[17] 钟萌, 谭群友, 冯悦, 等. 阿奇霉素囊泡体外释放行为的初步研究[J]. 中国抗生素杂志, 2012,37(6):476-480.
ZHONG Meng, TAN Qunyou, FENG Yue, et al. Preliminary study on the release of azithromycin niosomes in vitro[J]. Chinese Journal of Antibiotics, 2012,37(6):476-480.
[1] CHEN Ying, ZHOU Shuang, WEI Tianjing, FANG Haoxia, LI Yufei. Preparation and properties of polypyrrole composite fabric by soft template process [J]. Journal of Textile Research, 2019, 40(12): 93-97.
[2] WEI Yanhong, LIU Xinjin, XIE Chunping, SU Xuzhong, ZHANG Zhongxi. Shape retention and wearing properties of polyester filament/cotton composite yarn twill fabrics [J]. Journal of Textile Research, 2019, 40(12): 39-44.
[3] XIAO Zhitao, GUO Yongmin, GENG Lei, WU Jun, ZHANG Fang, WANG Wen, LIU Yanbei. Internal defect detection method for thin test pieces of woven laminated composites based on ultrasonic phased array [J]. Journal of Textile Research, 2019, 40(11): 81-87.
[4] YANG Enhui, QIU Hua, DAI Wenjie. Three-dimensional modeling and analysis of knitted fabric based on hexagonal mesh structure [J]. Journal of Textile Research, 2019, 40(11): 69-74.
[5] WU Ying, ZHAN Zhu, WANG Jun. Local fabric texture stability characterization using general dictionary [J]. Journal of Textile Research, 2019, 40(11): 45-49.
[6] JIA Gaopeng, SONG Xiaohong, LI Ying, LIU Xiaodan, PAN Xueru. Current response in stretching process of Cu-Ni metal-coated woven fabric [J]. Journal of Textile Research, 2019, 40(10): 68-72.
[7] QIAN Cheng, LIU Yanqing, LIU Xinjin, XIE Chunping, XU Bojun. Simulation and analysis of three-dimensional flow field in four-roller compact spinning system [J]. Journal of Textile Research, 2019, 40(10): 56-61.
[8] DONG Ke, ZHANG Ling, FAN Jiaxuan, LI Mengjie, MEI Lin, XIAO Xueliang. Action mechanism of wearing pressure on electrocardiogram monitoring of woven fabric electrodes [J]. Journal of Textile Research, 2019, 40(09): 75-82.
[9] LIU Muli, YUAN Li, YANG Yali, LIU Junping, CHENG Zhe, GONG Xue, JI Changjun, YAN Yuchen. Color representation model for pre-colored fiber blends based on independent component features from mixed color space [J]. Journal of Textile Research, 2019, 40(09): 62-69.
[10] HAN Jianjian, HU Yongjie, HU Minzhuan. Decolorization pretreatment method of quality inspection extraction solution based on nanofiltration technology [J]. Journal of Textile Research, 2019, 40(09): 136-142.
[11] ZOU Lihua, XU Zhenzhen, SUN Yanyan, WANG Tairan, QIU Yiping. Influence of graphene oxide/polyaniline functional film on electromagnetic shielding property of cotton fabrics [J]. Journal of Textile Research, 2019, 40(08): 109-116.
[12] SUN Weihong, RUAN Mianjiang, SHAO Tiefeng, LIANG Man. Detection method of cohesive performance of raw silk based on machine vision [J]. Journal of Textile Research, 2019, 40(08): 164-168.
[13] LIN Yongjia, YANG Dongchao, ZHANG Peihua, GU Yan. Preparation and properties of regenerated silk fibroin/acellular dermal matrix blended nanofiber membrane [J]. Journal of Textile Research, 2019, 40(07): 13-18.
[14] ZHU Hao, DING Hui, SHANG Yuanyuan, SHAO Zhuhong. Defect detection algorithm for multiple texture hierarchical fusion fabric [J]. Journal of Textile Research, 2019, 40(06): 117-124.
[15] ZHENG Zhenrong, ZHI Wei, HAN Chenchen, ZHAO Xiaoming, PEI Xiaoyuan. Numerical simulation of heat transfer of carbon fiber fabric under impact of heat flux [J]. Journal of Textile Research, 2019, 40(06): 38-43.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
京ICP备14006648号
Copyright 2021 © Editorial office of Journal of Textile Research
Supported by Beijing Magtech Co.Ltd