Journal of Textile Research ›› 2020, Vol. 41 ›› Issue (02): 20-25.doi: 10.13475/j.fzxb.20190403107

• Fiber Materials • Previous Articles     Next Articles

Preparation of poly(aspartic acid) based fiber hydrogel and its drug release behavior

LI Sijie, ZHANG Caidan()   

  1. College of Material and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang 314000, China
  • Received:2019-04-08 Revised:2019-11-24 Online:2020-02-15 Published:2020-02-21
  • Contact: ZHANG Caidan E-mail:caidanzhang@126.com

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Abstract:

To develop a sustained drug delivery system with pH sensitivity, polysuccinimide (PSI), as the intermediate of pH-sensitive polyaspartic acid (PASP), and thermoplastic polyurethane (TPU) were used to produce electro-spun membranes, with 5-fluorouracil being the model drug. The PSI/TPU fiber membrane with skin-core structure was prepared by coaxial electrospinning. Then PASP/TPU fiber hydrogel based drug-loading system was obtained by post-treatment of PSI/TPU fiber membrane. The effects of electro-spinning parameters and post-treatment on fiber membrane morphology, chemical structure, mechanical properties and swelling properties were analyzed. The drug release behavior of PASP/TPU fiber hydrogel in vitro was studied. The results show that PASP/TPU fiber hydrogel is gained by crosslinking and hydrolysis of PSI/TPU fiber membrane. With the increase of inner layer flow rate during coaxial electrospinning, the core thickness and mechanical properties of PASP/TPU fiber hydrogel increase, while the swelling ratio of PASP/TPU fiber hydrogel decreases. In addition, PASP/TPU fiber hydrogel with pH sensitivity exhibits swelling ratio increase when increasing the pH value. Drug release rate of PASP/TPU nanofiber hydrogel in vitro varies according to the pH value of release medium.

Key words: pH sensitivity material, fiber hydrogel, coaxial electrospinning, polyaspartic acid, sustained drug delivery

CLC Number: 

  • TS101.4

Fig.1

SEM and TEM images of PSI/TPU fiber membranes with different core flow rate. (a)0.5 mL/h(×3 000);(b)1.0 mL/h(×3 000);(c)1.5 mL/h(×3 000);(d)TEM image(×100 000)"

Fig.2

SEM images of PASP/TPU fiber hydrogel with different core flow rate(×3 000)"

Fig.3

FT-IR spectra of different fiber membranes"

Fig.4

Illustration of PSI generated into PASP hydrogel with crosslinking and hydrolysis"

Fig.5

Tensile curve of PSI/TPU fiber membranes(a)and PASP/TPU fiber hydrogel(b) with different core flow rate"

Fig.6

Swelling ratio curve of PASP/TPU fiber hydrogel with different pH value"

Fig.7

Standard curve of 5-fluorouracil"

Fig.8

In vitro drug release curves of drug loaded PASP/TPU fiber hydrogel. (a) Different core flow rate; (b) Different pH value"

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