Journal of Textile Research ›› 2020, Vol. 41 ›› Issue (07): 15-22.doi: 10.13475/j.fzxb.20191000408

• Fiber Materials • Previous Articles     Next Articles

Construction and drug release properties of fiber-based mesoporous SiO2 drug carrier

DUAN Hongmei, WANG Ximing, HUANG Zixin, GAO Jing(), WANG Lu   

  1. College of Textiles, Donghua University, Shanghai 201620, China
  • Received:2019-10-08 Revised:2020-01-20 Online:2020-07-15 Published:2020-07-23
  • Contact: GAO Jing E-mail:gao2001jing@dhu.edu.cn

RichHTML

5

PDF (PC)

138

Abstract:

In order to study the drug releasing performance of fiber-based mesoporous SiO2, mesoporous SiO2 nanoparticles was prepared using sol-gel method, and the polycaprolactone (PCL) fiber membranes loaded with mesoporous SiO2 nanoparticles were prepared by electrospinning. The antibacterial drug ciprofloxacin hydrochloride was loaded into mesoporous SiO2 nanoparticles, and the releasing properties and releasing mechanism of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes were investigated under acidic conditions. The results show that the formation of mesoporous SiO2 nanoparticles is greatly affected by pH value. Within the moldable range, the particle size of the nanoparticles increases with increasing pH value. As the proportion of mesoporous SiO2 nanoparticles increases, the fineness of PCL composite fibers gradually decreases. The release of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes has a large initial release rate and a slow release in the later stage, the cumulative release rate in the two carriers within 12 h reaches 55.51% and 16.53%, respectively. The results of kinetic studies on the two drug release models indicate that diffusion is the main mechanism of drug release.

Key words: mesoporous silica, nanofiber membrane, ciprofloxacin hydrochloride, drug loading, drug release

CLC Number: 

  • TS101.4

Fig.1

TEM images of MSNs obtained by reaction at different pH value"

Fig.2

FT-IR spectra of MSNs before and after calcination at 550 ℃"

Fig.3

SAXD pattern of MSNs"

Fig.4

N2 adsorption-desorption isotherms(a) and pore size distribution of MSNs(b)"

Fig.5

Standard curve of Cip in aqueous solution(a) and in pH=5.4 PBS buffer(b)"

Fig.6

Effect of drug solution concentration on encapsulation efficiency and drug loading of MSNs"

Fig.7

SEM images of Cip-MSNs/PCL composite fiber membrane with different MSNs mass fraction"

Fig.8

EDX analysis of Cip-MSNs/PCL composite fiber membrane. (a) Distribution of Si; (b)Distribution of F"

Fig.9

In vitro release profile of Cip in different drug carriers"

Fig.10

Fitting of kinetic model of drug Cip release in different carriers"

[1] MOSTAFALU P, KIAEE G, GIATSIDIS G, et al. A textile dressing for temporal and dosage controlled drug delivery[J]. Advanced Functional Materials, 2017,27(41):10.
[2] KIAEE G, MOSTAFALU P, SAMANDARI M, et al. A pH-mediated electronic wound dressing for controlled drug delivery[J]. Advanced Healthcare Materials, 2018,7(18):8.
[3] MOSTAFALU P, TAMAYOL A, RAHIMI R, et al. Smart bandage for monitoring and treatment of chronic wounds[J]. Small, 2018,14(33):9.
[4] 苏金玲. 湿性敷料在慢性伤口中的应用研究进展[J]. 微创医学, 2019,14(3):364-366.
SU Jinling. Progress in the application of wet dressings in chronic wounds[J]. Minimally Invasive Medicine, 2019,14(3):364-366.
[5] VALLET-REGI M, RAMILA A, DELREAL R P, et al. A new property of MCM-41: drug delivery system[J]. Chemistry of Materials, 2001,13(2):308-311.
[6] LI H, KE J, LI H T, et al. Mesoporous silicas templated by heterocyclic amino acid derivatives: biomimetic synjournal and drug release application[J]. Materials Science & Engineering C: Materials for Biological Applications, 2018,93:407-418.
doi: 10.1016/j.msec.2018.07.081 pmid: 30274073
[7] 姚云飞, 朱海霖, 冯新星, 等. 介孔硅载银抗菌剂的结构及其抗菌性能[J]. 纺织学报, 2012,33(2):80-84.
YAO Yunfei, ZHU Hailing, FENG Xinxing, et al. Structure and antibacterial performance of silver-supportedmesoporous silica antibacterial agent[J]. Journal of Textile Research, 2012,33(2):80-84.
[8] 孙斌, 陈建勇, 周岚, 等. 载银介孔SBA-15抗菌剂的制备及表征[J]. 纺织学报, 2011,32(6):104-108.
SUN Bin, CHEN Jianyong, ZHOU Lan, et al. Preparation and characterization of Ag loaded mesoporous SBA-15 antibacterial agent and its characterization[J]. Journal of Textile Research, 2011,32(6):104-108.
[9] AGHAEI H, NOURBAKHSH A A, KARBASI S, et al. Investigation on bioactivity and cytotoxicity of mesoporous nano-composite MCM-48/hydroxyapatite for ibuprofen drug delivery[J]. Ceramics International, 2014,40(5):7355-7362.
[10] 康卫民, 范兰兰, 邓南平, 等. 静电纺丝多孔碳纳米纤维制备与应用研究进展[J]. 纺织学报, 2017,38(11):168-176.
KANG Weimin, FAN Lanlan, DENG Nanping, et al. Research progress in preparation and application of electrospinning porous carbon nanofibers[J]. Journal of Textile Research, 2017,38(11):168-176.
[11] TAN L, HU J L, ZHAO H F. Design of bilayered nanofibrous mats for wound dressing using an electrospinning technique[J]. Materials Letters, 2015,156:46-49.
[12] DASHDORJ U, REYES M K, UNNITHAN A R, et al. Fabrication and characterization of electrospun zein/Ag nanocomposite mats for wound dressing applications[J]. International Journal of Biological Macromolecules, 2015,80:1-7.
doi: 10.1016/j.ijbiomac.2015.06.026 pmid: 26093320
[13] KANG Y O, IM J N, PARK W H. Morphological and permeable properties of antibacterial double-layered composite nonwovens consisting of microfibers and nanofibers[J]. Composites Part B: Engineering, 2015,75:256-263.
[14] LUO X M, XIE C Y, WANG H, et al. Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implanta-tion[J]. International Journal of Pharmaceutics, 2012,425(1/2):19-28.
doi: 10.1016/j.ijpharm.2012.01.012
[15] MOLLER K, KOBLER J, BEIN T. Colloidal suspensions of mercapto-functionalized nanosized mesoporous silica[J]. Journal of Materials Chemistry, 2007,17(7):624-631.
doi: 10.1039/B611931J
[16] 吴焕岭. 载药再生细菌纤维素纤维的制备及其表征[J]. 纺织学报, 2017,38(5):14-18.
WU Huanling. Preparation and characterization of drug-loaded regenerated bacterial cellulose fiber[J]. Journal of Textile Research, 2017,38(5):14-18.
[17] 徐瑞芳, 谢晓静, 高晶, 等. 敷料用介孔硅基盐酸环丙沙星缓释颗粒的制备及性能[J]. 东华大学学报(自然科学版), 2019,45(2):256-262,269.
XU Ruifang, XIE Xiaojing, GAO Jing, et al. Prepration and properties of control-released particles of ciprofloxacin hydrochloride loaded mesoporous silica for wound dressing[J]. Journal of Donghua University (Natural Science), 2019,45(2):256-262,269.
[18] HERRMANN I, SUPRIYANTO E, JAGANATHAN S K, et al. Advanced nanofibrous textile-based dressing material for treating chronic wounds[J]. Bulletin of Materials Science, 2018,41(1):10.
doi: 10.1007/s12034-017-1525-7
[19] TAKAHASHI K, OHTA T. Inflammatory acidic pH enhances hydrogen sulfide-induced transient receptor potential ankyrin 1 activation in RIN-14B cells[J]. Journal of Neuroscience Research, 2013,91(10):1322-1327.
doi: 10.1002/jnr.23251 pmid: 23873754
[20] ANDERSSON J, ROSENHOLM J, AREVA S, et al. Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices[J]. Chemistry of Materials, 2004,16(21):4160-4167.
doi: 10.1021/cm0401490
[21] ABDALKARIM S Y H, YU H, WANG C, et al. Thermo and light-responsive phase change nanofibers with high energy storage efficiency for energy storage and thermally regulated on-off drug release devices[J]. Chemical Engineering Journal, 2019,375. DOI: 10.1016/j.cej.2019.121979.
[22] YANG P P, GAI S L, LIN J. Functionalized mesoporous silica materials for controlled drug delivery[J]. Chemical Society Reviews, 2012,41(9):3679-3698.
pmid: 22441299
[23] CUELLO N I, ELIAS V R, MENDIETA S N, et al. Drug release profiles of modified MCM-41 with superparamagnetic behavior correlated with the employed synjournal method[J]. Materials Science & Engineering C: Materials for Biological Applications, 2017,78:674-681.
doi: 10.1016/j.msec.2017.02.010 pmid: 28576037
[1] PAN Lu, CHENG Tingting, XU Lan. Preparation of polycaprolactone/polyethylene glycol nanofiber membranes with large pore sizes and its application for tissue engineering scaffold [J]. Journal of Textile Research, 2020, 41(09): 167-173.
[2] WU Hong, LIU Chengkun, MAO Xue, YANG Zhi, CHEN Meiyu. Research progress in preparation and application of flexible zirconia nanofibers by electrospinning [J]. Journal of Textile Research, 2020, 41(07): 167-173.
[3] WU Heng, JIN Xin, WANG Wenyu, ZHU Zhengtao, LIN Tong, NIU Jiarong. Preparation and piezoelectric properties of polyacrylonitrile / sodium nitrate nanofiber membrane [J]. Journal of Textile Research, 2020, 41(03): 26-32.
[4] WANG Jie, ZHOU Mingwei, WANG Bin, LI Xiuyan. Optimization design and preparation of nanofiber membrane based flexible pressure sensor [J]. Journal of Textile Research, 2019, 40(11): 32-37.
[5] GAO Shangpeng, HUANG Qinglin, DAI Wei, XIAO Changfa. Preparation and properties of polyvinylidene fluoride photothermal nanofiber membrane [J]. Journal of Textile Research, 2019, 40(08): 1-6.
[6] . Adsorption properties of cotton fiber functionalized by mesoporous nanoparticle for dyes [J]. Journal of Textile Research, 2018, 39(10): 93-98.
[7] . Preparation and properties of electrospun polyacrylonitrile / copper sulfate nanofibrous membrane [J]. JOURNAL OF TEXTILE RESEARCH, 2018, 39(07): 15-20.
[8] . Adsorbability of modified poly(vinyl alcohol-co-ethylene) nanofiber membrane to heavy metal ions [J]. JOURNAL OF TEXTILE RESEARCH, 2017, 38(06): 11-16.
[9] . Preparation and waterproof and water-permeable properties of electrospun fluorinated polyurethanel polyurethane [J]. JOURNAL OF TEXTILE RESEARCH, 2016, 37(10): 83-88.
[10] . Research on the system of a novel polyglycolic acid nanofibers scaffold loaded drug [J]. JOURNAL OF TEXTILE RESEARCH, 2014, 35(12): 6-0.
[11] . Antibacterial mechanism and performance of PLA/TP composed nanofiber membrane [J]. JOURNAL OF TEXTILE RESEARCH, 2013, 34(8): 6-0.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
京ICP备14006648号
Copyright 2021 © Editorial office of Journal of Textile Research
Supported by Beijing Magtech Co.Ltd