Journal of Textile Research ›› 2020, Vol. 41 ›› Issue (09): 174-182.doi: 10.13475/j.fzxb.20191104309

• Column: Biomedical Textile Materials and It′s Products • Previous Articles     Next Articles

Preparation and cytotoxicity analysis of flexible metal electrodes for medical dressings

HAN Jiarui, HUANG Zhenzhen, WANG Jiajun, YIN Hao, GAO Jing(), LAO Jihong, WANG Lu   

  1. College of Textiles, Donghua University, Shanghai 201620, China
  • Received:2019-11-20 Revised:2020-05-06 Online:2020-09-15 Published:2020-09-25
  • Contact: GAO Jing E-mail:gao2001jing@dhu.edu.cn

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Abstract:

In order to study the feasibility and safety of the preparation of flexible metal electrodes for medical dressings, a flexible micro-current biomedical dressing was prepared, taking a polyester nonwoven fabric as the base fabric, by the screen printing technique, where zinc was used for the negative electrode and silver the positive. The effects of dispersant type, dispersant content and binder content on the electrical properties of the metal electrodes were discussed, and the possible cytotoxicity problems caused by the metal electrodes were studied. The results show that the screen printing technique made the silver and zinc micro-nano particles adhere to the fabric surface uniformly. 1% carboxy methyl cellulose sodium(CMC) and 0.5% Tween-80 are found to be the optimal condition for good dispersion of the zinc and silver particles. Waterborne acrylic emulsion with mass fraction of 5% and 15% enabled zinc and silver metal electrodes to have excellent electrical properties respectively. The metal electrodes show good cytocompatibility with 0.5%-1.0% metal content, which is suitable for biomedical dressings to provide exogenous micro-current for the wound.

Key words: medical dressings, flexible metal electrode, cytotoxicity, bioelectric dressings

CLC Number: 

  • TS111.8

Tab.1

Printing ink ratio of zinc electrode"

锌电极编号 质量/g
Zn AAE SA CMC分散液
A 3.0 0.5 0.2 6.3
B 3.0 1.0 0.2 5.8
C 3.0 1.5 0.2 5.3
D 3.0 2.0 0.2 4.8
E 0.0 0.5 0.2 9.3

Tab.2

Printing ink ratio of silver electrode"

银电极编号 质量/g
银粉 AAE SA Tween-80分散液
A 3.0 0.5 0.2 6.3
B 3.0 1.0 0.2 5.8
C 3.0 1.5 0.2 5.3
D 3.0 2.0 0.2 4.8

Tab.3

Printing ink ratio of zinc and silver flexible electrode pairs"

基布编号 电极 质量/g
AAE 金属 SA 分散液
Ⅰ 锌电极 5.00 0.50 2.00 92.50
银电极 15.00 0.50 2.00 82.50
Ⅱ 锌电极 5.00 0.75 2.00 92.25
银电极 15.00 0.75 2.00 82.25
Ⅲ 锌电极 5.00 1.00 2.00 92.00
银电极 15.00 1.00 2.00 82.00
Ⅳ 锌电极 5.00 3.00 2.00 90.00
银电极 15.00 3.00 2.00 80.00
Ⅴ 锌电极 5.00 5.00 2.00 88.00
银电极 15.00 5.00 2.00 78.00

Tab.4

Dispersion viscosity of different dispersants"

分散剂名称 黏度/(mPa·s)
Tween-80 118.00±5.60
PEG 100.00±2.80
CMC 8 045.44±10.76

Tab.5

Dispersion viscosity of different mass fractions of CMC"

CMC质量分数/% 黏度/(mPa·s)
0.5 2 704.00±27.80
1.0 8 045.44±10.76
1.5 18 215.56±222.13
2.0 40 826.67±473.41

Fig.1

Settling height of zinc powder in different dispersant systems"

Tab.6

Relative liquid level height of zinc dispersion systems under different mass fractions of CMC at 0 h"

CMC质量分数/% 相对液面高度/cm
0.5 2.67
1.0 2.63
1.5 2.60
2.0 2.52

Fig.2

Settlement height of zinc dispersion systems under different concentrations of CMC"

Fig.3

Absorbance of nano-silver dispersions with different dispersants"

Fig.4

SEM images of different zinc electrodes and based fabric (×3 000). (a) Zinc electrodes A; (b) Zinc electrodes B;(c) Zinc electrodes C; (d) Zinc electrodes D;(e)Based fabric"

Fig.5

XRD image of different zinc electrodes, zinc powder and polyester non-woven"

Fig.6

EDS image of different zinc electrode. (a) Zinc electrodes A; (b) Zinc electrodes B;(c) Zinc electrodes C;(d) Zinc electrodes D"

Fig.7

Voltages of different zinc electrodes"

Fig.8

SEM images of different silver electrodes and based fabric(×3 000). (a) Silver electrodes A'; (b) Silverelectrodes B'; (c) Silver electrodes C'; (d) Silver electrodes D'; (e)Based fabric"

Fig.9

XRD image of different silver electrodes, silver powder and polyester non-woven"

Fig.10

EDS image of different silver electrode. (a) Silver electrodes A'; (b) Silver electrodes B';(c) Silver electrodes C'; (d) Silver electrodes D'"

Fig.11

Voltages of silver electrodes with different mass fractions of AAE"

Fig.12

Apparent morphology of striped Ag/Zn electrode pairs"

Tab.7

Proliferation rate of cells in based fabric Ⅲ"

样品种类 细胞增殖率/%
条纹状基布Ⅲ 81.06±2.37
阴性对照 100.00±0.00
阳性对照 22.45±1.54

Fig.13

Proliferation rate of multiple dilution cells in based fabric"

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