Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (07): 193-199.doi: 10.13475/j.fzxb.20201207107

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Research progress in functional dressings for scar inhibition in wound healing

SONG Ziyu1, ZHAO Juyang1, QIN Yue1, HUANG Xiaorui1, GAO Jing1,2(), WANG Lu1,2   

  1. 1. College of Textiles, Donghua University, Shanghai 201620, China
    2. Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, Donghua University, Shanghai 201620, China
  • Received:2020-12-28 Revised:2021-05-31 Online:2022-07-15 Published:2022-07-29
  • Contact: GAO Jing E-mail:gao2001jing@dhu.edu.cn

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Abstract:

In order to achieve scarless cutaneous wound healing, a summary of the relevant researches at home and abroad on the effect of functional dressings on inhibiting scarring was reviewed and summarized. The wound healing process was reviewed in the first place, concentrating on the factors affecting scar formation, namely external environment and internal biological signal regulation, the performance requirements of scar-inhibiting dressings under different physiological environments and demands at different stages of wound healing. At the three stages of inflammation, proliferation and remodeling, functional dressings inhibit scarring by reducing inflammatory response, regulating signal transduction and promoting tissue regeneration, respectively. Studies have shown that scar formation is a dynamic, continuous and complex process involving inflammatory cells, keratinocytes, fibroblasts and various growth factors. Therefore, in order to achieve better effect of functional dressings used to suppress scars, it is necessary to pay attention to the research of new drug delivery systems and the optimal design of dressings structures.

Key words: functional dressing, scar inhibition, inflammatory response, fibroblast, TGF-β/Smad signal, extracellular matrix, collagen

CLC Number: 

  • TS101.4

Fig.1

Influence mechanism of inflammatory response on scar formation"

Fig.2

TGF-β/Smad signaling pathway"

Tab.1

Measures to inhibit scars in each stage of wound healing"

愈合阶段 目的 相关因素 实现方式 参考文献
炎症期 降低炎症反应 炎症细胞多 抗菌 [4,15⇓⇓⇓-19]
氧气少 抗氧化 [20-21]
增殖期 调控信号传导 角质形成细胞与成纤维细胞间的信号通路 保持创面湿润 [23⇓⇓-26,29,31]
TGF-β/Smad信号通路 阻断信号传导 [1,7,32⇓⇓⇓-36]
重塑期 促进组织再生 成纤维细胞增殖分化 控制分化 [38⇓-40]
ECM变化 增加胶原酶活性,控制Ⅰ/Ⅲ型胶原合成 [37,41⇓⇓-44,49-50]
血管和皮肤附属物缺失 促进血管生成和正常皮肤组织再生 [45⇓⇓-48]
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