Journal of Textile Research ›› 2021, Vol. 42 ›› Issue (05): 1-8.doi: 10.13475/j.fzxb.20210106008

• Invited Paper •     Next Articles

Preparation and biomedical applications of electrospun short fibers

ZHANG Beilei, SHEN Mingwu, SHI Xiangyang()   

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
  • Received:2021-01-25 Revised:2021-02-15 Online:2021-05-15 Published:2021-05-20
  • Contact: SHI Xiangyang E-mail:xshi@dhu.edu.cn

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Abstract:

Traditional electrospun nanofibers are often used as tissue engineering scaffolds to repair defects, which often need invasive implantation by surgery, greatly limiting their applications in biomedical fields. In order to promote the development and applications of electrospinning technology, this paper reviewed the preparation and functionalization methods of electrospun short fibers, the biomedical applications of functional short fiber in diagnosis and therapy, and tissue engineering. Electrospun short fibers have received great attention and can be prepared by adjusting process parameters and subsequent processing. Electrospun short fibers retain their intrinsic functions of electrospun nanofiber membranes, they can avoid the invasion and trauma caused by the implantation of fiber membranes because of their small size and monodispersity. The challenges and future development prospects of electrospun short fibers in biomedical fields were also analyzed.

Key words: electrospinning, nanofiber, functional short fiber, diagnostic testing, tumor therapy, tissue engineering

CLC Number: 

  • TS101

Tab.1

Summary of preparation and functionalization of electrospun short fibers"

基底聚合物纤维 制备方法 功能物质 功能化方法 功能 参考文献
PLGA 冷冻切片 SPION 物理掺杂 磁响应,指导细胞行为 [24]
PAN 均质处理 Fe3O4纳米颗粒、GO 物理掺杂 提高生物安全性,指导细胞行为 [26]
BG 超声破碎 Sr(NO3)2、CuCl2 物理掺杂 促进新骨和血管生成 [11]
PELA 冷冻切片 HCPT 物理掺杂 抗肿瘤(化疗) [27]
CDM/PELA 冷冻切片 PMCPT 物理掺杂 抗肿瘤(靶向识别和还原刺激响应) [28]
PLA-cdm 冷冻切片 PMCPT 化学键合 抗肿瘤(靶向识别和还原刺激响应) [29]
PLLA 冷冻切片 GDNF 化学键合 促进细胞存活和轴突生长 [30]
PEI/PVA 均质处理 Fe3O4@PEI、 DNA适配体 综合改性 捕获和分离CTCs [31]
PCL/gelatin 冷冻切片、超声破碎 GelMA、BMP-2、QK 综合改性 促进新骨和血管生成 [25]

Fig.1

Schematic illustration of fabrication of PCL-PEG-PCL TNSs by a four-step process"

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