Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (06): 49-56.doi: 10.13475/j.fzxb.20210503908

• Fiber Materials • Previous Articles     Next Articles

Preparation and properties of nanofiber-based unidirectional water-transport antibacterial wound dressings

OU Kangkang1,2,3, QI Linya1, HOU Yijun1, FAN Tianhua1, QI Kun1(), WANG Baoxiu2, WANG Huaping2,3   

  1. 1. Research Institute of Textile and Clothing Industries, Zhongyuan University of Technology, Zhengzhou, Henan 451191, China
    2. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China
    3. National Advanced Functional Fiber Innovation Center, Suzhou, Jiangsu 215228, China
  • Received:2021-05-17 Revised:2021-12-22 Online:2022-06-15 Published:2022-07-15
  • Contact: QI Kun E-mail:qikun@zut.edu.cn

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Abstract:

In order to deal with bacteria breeding and fluid formation on wound site, polyurethane (PU) with excellent mechanical properties, polyacrylonitrile with high hydrophilicity and sodium polyacrylate with superabsorbent water were used as the substrate, and polyhexamethyl guanidine hydrochloride (PHGC) was used as the antibacterial agent to create antibacterial wound dressings. The nanofiber-based bilayer dressing material composed of hydrophilic outer layer and hydrophobic inner layer with different fiber sizes was prepared by electrospinning. The influence of hydrophobic layer thickness on the unidirectional water-transport effect of bilayer dressing was investigated, and the relationship between the structure and properties of the dressing were analyzed. The results show that the prepared bilayer dressing material can transfer water unidirectionally from inside to outside in 3.9 s, and the water absorption of the dressing is as high as 1 230%. The air permeability is 6.7 mm/s, the moisture permeability is 1 350 g/(m2·d), the breaking strength is 6.5 MPa and the elongation at break is 45%. The addition of 0.06% PHGC to PU inner layer makes the antibacterial rate of dressing against Escherichia coli and Staphylococcus aureus reach more than 95%. The prepared bilayer dressings show no cytotoxicity and low cell adhesion.

Key words: wound dressing, electrospinning, unidirectional water-transport, antibacterial property, nanofiber

CLC Number: 

  • TS174.1

Fig.1

Morphology, diameter distribution and water contact angle of nanofiber dressing. (a) Inner layer PU-PHGC membrane; (b) Outer layer PAN/PU-SPA membrane; (c) Cross-section of bilayer dressing and contact angle of inner and outer layer membrane"

Fig.2

Dynamic water contact angle of inner layer(a),outer layer(b) and inner layer of bilayer dressing PU-1 (c), PU-2(d) and PU-3(e)"

Fig.3

Diffusion process of ink drops on samples. (a) Inner layer; (b) Outer layer; (c) Front side of bilayer dressing; (d) Reversal side of bilayer dressing"

Fig.4

Transmission process of water droplets on both sides of dressing. (a) Forward direction; (b) Negative direction"

Tab.1

Physical performance of bilayer dressing"

样品 透气率/
(mm·s-1)		 透湿率/
(g·m-2·d-1)		 平衡含
水量/%		 吸水
率/%		 断裂
强度/
MPa		 断裂
伸长
率/%
内层 6.2±0.2 1 350±23 78±1.0 377±23 6.0±0.5 40±5
外层 7.5±0.1 1 970±25 93±0.6 970±27 8.0±0.5 80±5
双层
敷料		 6.7±0.5 1 350±20 92±2.0 1 230±50 6.5±0.5 45±5

Fig.5

TG curves of PHGC and bilayer dressing"

Fig.6

FT-IR spectra of PHGC, PU-PHGC and PU nanofibrous membrane"

Fig.7

Antibacterial properties of bilayer dressing.(a) Blank sample; (b) Bilayer dressing"

Fig.8

Effect of control, inner and outer membrane, and dressing extracts on cell viability of GES-1"

Fig.9

Bio-adhesion effect of bilayer dressings culturing 48h. (a) Front side; (b) Reverse side"

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