Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (12): 190-196.doi: 10.13475/j.fzxb.20210805407

• Comprehensive Review • Previous Articles     Next Articles

Research progress in fiber-based artificial nerve guide conduits

DAI Jiamu, NIE Du, LI Suying, ZHANG Yu, ZHANG Wei, LIU Rong()   

  1. School of Textile and Clothing, Nantong University, Nantong, Jiangsu 226019, China
  • Received:2021-08-11 Revised:2022-04-16 Online:2022-12-15 Published:2023-01-06
  • Contact: LIU Rong E-mail:rong063@ntu.edu.cn

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Abstract:

For the purpose of developing artificial nerve guide conduit (NGC) with good biocompatibility, multi-function and excellent nerve regeneration capacity, raw materials component, fabrication method, structure designing, functionalizing and cell incubation of the scaffolds as well as the analysis of future research directions were reviewed. Literature showed that fiber-based NGC with different diameters were prepared using natural, synthesized polymers, or mixed materials, by various methods such as melt spinning, electrospinning and self-assembling. In general, hollow tubular scaffolds were filled with sponge, hydrogel or axial channel to improve the orientated growth of cells to provide appropriate micro environment for cell growth. Through modifying with electro-conductive or magnetic materials, loading active substances such as growth factors or messenger RNA (mRNA), would accelerate cell proliferation and differentiation. Subsequently, the potential development directions of NGC are proposed to further improve the efficiency of nerve regeneration.

Key words: artificial nerve guide conduit, fiber-based scaffold, growth factor, functionalization

CLC Number: 

  • TS106.5

Fig.1

Fabrication processes of different nerve guide conduit scaffolds with various structure. (a) Scaffold filled with nanofibers;(b) Compound scaffold with uniform longitudinally oriented guidance;(c) Thermally drawn fibers scaffold;(d) Injectable hybrid hydrogel with oriented short fibers"

Fig.2

Preparation method of functionalized fiber-based nerve guide conduit scaffolds. (a) Electro-conductive modification; (b) Magnetic nanoparticles functionalization; (c) Growth factor loading ; (d) Laminin-coated modification"

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