Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (11): 1-8.doi: 10.13475/j.fzxb.20210908508

• Fiber Materials •     Next Articles

Preparation and characterization of polylactic acid nanofiber drug loaded medical dressings

LI Liang1, PEI Feifei2, LIU Shuping3, TIAN Sujie4, XU Mengyuan3, LIU Rangtong3(), HAI Jun1   

  1. 1. Textile College, Zhongyuan University of Technology, Zhengzhou, Henan 451191, China
    2. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
    3. Fashion Technology College, Zhongyuan University of Technology, Zhengzhou, Henan 451191, China
    4. College of Textile Science and Engineering, Jiangnan University,Wuxi, Jiangsu 214122, China
  • Received:2021-09-22 Revised:2022-03-17 Online:2022-11-15 Published:2022-12-26
  • Contact: LIU Rangtong E-mail:ranton@126.com

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Abstract:

In order to construct a self-degradable, antibacterial, anti-inflammatory, light, thin and soft medical dressings conducive to wound healing, nanofiber drug loaded dressings based on polylactic acid (PLA) was prepared by electrospinning technology with different mass fractions of amoxicillin. The microstructure, wettability, drug release, antibacterial and self-degradation properties of nanofiber films were analyzed by means of scanning electron microscope, infrared spectrometer, X-ray diffraction, contact angle tester and UV spectrophotometer. The results indicate that the PLA nanofiber dressings possess porous structure and the diameter of dressing fiber decreases with the increase of drug loading. When the drug loading is 3%, the average diameter of dressing fiber is 684 nm. There is no chemical reaction between amoxicillin and polylactic acid, suggesting that negative modification did not occur for the amoxicillin. Moreover, the wettability and antibacterial properties of drug loaded PLA nanofiber dressings are enhanced with the increase of drug loading. The antibacterial rate of nanofiber dressings with 3% drug loading is up to 91% for staphylococcus aureus. In addition, polylactic acid nanofiber dressings represent excellent in-vitro degradation performance, drug release ability and stable release rate, which are necessary for wound dressings.

Key words: polyalctic acid, nanofiber, medical dressings, antibacterial, drug sustained release

CLC Number: 

  • TS174.8

Fig.1

SEM images of polylactic acid nanofiber drug loaded dressing(×20 000). (a) Polylactic acid nanofiber; (b) Doped with 1% amoxicillin; (c) Doped with 2% amoxicillin;(d) Doped with 3% amoxicillin"

Fig.2

Fiber diameter distribution histogram of polylactic acid nanofiber drug loaded dressing. (a) Polylactic acid nanofiber; (b) Doped with 1% amoxicillin; (c) Doped with 2% amoxicillin; (d) Doped with 3% amoxicillin"

Tab.1

Solution property of PLA with different drug loadings"

载药量/% 黏度/(mPa·s) 电导率/(μS·cm-1)
0 74.2 1.56
1 69.4 1.97
2 66.8 2.52
3 67.1 2.84

Fig.3

Infrared spectra of polylactic acid nanofiber drug loaded dressing"

Fig.4

X-ray diffraction pattern of polylactic acid nanofiber drug loaded dressing"

Fig.5

Contact angle of polylactic acid nanofiber drug loaded dressing"

Fig.6

Degradation mechanism of polylactic acid nanofibers"

Fig.7

Degradation curve of polylactic acid nanofiber drug loaded dressing"

Fig.8

Simulated cumulative release curve of polylactic acid nanofiber drug loaded dressing in vitro"

Fig.9

Amoxicillin structural formula"

Fig.10

Antibacterial rate of polylactic acid nanofiber drug loaded dressing"

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