Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (12): 16-21.doi: 10.13475/j.fzxb.20211106106

• Fiber Materials • Previous Articles     Next Articles

Structure and mechanical properties of three-dimensional porous biodegradable polymer artificial esophageal scaffold

WANG Shudong1,2,3()   

  1. 1. School of Textile and Clothing, Yancheng Polytechnic College, Yancheng, Jiangsu 224005, China
    2. College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215002, China
    3. Jiangsu Jinmaisui New Energy Technology Co., Ltd., Yancheng, Jiangsu 224000, China
  • Received:2021-11-11 Revised:2022-02-27 Online:2022-12-15 Published:2023-01-06

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Abstract:

In order to meet the requirements of artificial esophageal scaffolds on material's structure and mechanical properties, three-dimensional porous biodegradable polymer artificial esophageal scaffolds were prepared with biodegradable polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA) as raw materials, cylindrical polytetrafluoroethylene as template and sodium chloride as porogen. Morphology, microstructure and mechanical properties were characterized. The results show that the PLA and PLGA artificial esophageal scaffolds have three-dimensional porous structure. After ethanol treatment, the length, diameter and porosity of the esophageal scaffolds decrease to a certain extent. Microstructure of PLA and PLGA three-dimensional porous esophageal scaffolds is amorphous. Ethanol treatment improves the crystallinity of the two esophageal scaffolds to a certain extent. The breaking strength and suture strength of the PLA and PLGA esophageal scaffolds are (2.68±0.46) MPa, (3.68±0.98) N and (1.53±0.21) MPa, (2.21±0.65) N, respectively. After ethanol treatment, the tensile strength and suture strength of these two esophageal scaffolds are improved to a certain extent. The suture strength of the two esophageal scaffolds exceeds the suture strength that the scaffolds could bear during esophageal scaffolds transplantation.

Key words: artificial esophageal scaffold, polylactic acid, polylactic acid-glycdic acid copolymer, biodegradability, structure, mechanical property

CLC Number: 

  • TS102.512

Fig.1

Morphology photos of three-dimensional porous esophageal scaffolds. (a) PLA esophageal scaffold; (b) PLA-1#and PLA-2#; (c) PLGA esophageal scaffold; (d) PLGA-3# and PLGA-4#"

Tab.1

Size of three-dimensional porous esophageal scaffolds"

样品编号 长度/cm 管径/mm 壁厚/mm 孔隙率/%
1# 10.0 9.9 2.2 69.3
2# 9.9 9.8 2.1 61.9
3# 9.9 10.1 1.8 65.6
4# 9.8 9.9 1.7 58.3

Fig.2

SEM images of three-dimensional porous biodegradable polymer artificial esophageal scaffolds"

Fig.3

FT-IR spectra of three-dimensional porous esophageal scaffolds"

Fig.4

XRD spectra of three-dimensional porous biodegradable polymer artificial esophageal scaffolds"

Fig.5

Thermal properties of three-dimensional porous esophageal scaffolds. (a) TG curves; (b) TGA curves; (c) DSC curves"

Tab.2

Mechanical properties of three-dimensional porous esophageal scaffolds"

样品
编号		 断裂强
度/MPa		 断裂伸
长率/%		 弹性模
量/MPa		 缝合强
力/N
1# 2.68±0.46 38.56±3.35 6.95±0.35 3.68±0.98
2# 2.97±0.38 32.37±2.76 9.18±0.27 4.02±1.32
3# 1.53±0.21 46.79±4.21 3.27±0.23 2.21±0.65
4# 1.84±0.26 44.28±3.82 4.16±0.19 2.86±0.78
[1] BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians, 2018, 68:394-424.
doi: 10.3322/caac.21492 pmid: 30207593
[2] DENG J, CHEN H, ZHOU D, et al. Comparative genomic analysis of esophageal squamous cell carcinoma between Asian and Caucasian patient populations[J]. Nature Communications, 2017. DOI:10.1038/s41467-017-01730-x.
doi: 10.1038/s41467-017-01730-x
[3] ZHU Y, ZHOU M, HOU R. Tissue engineering of esophagus[M]. London: IntechOpen, 2017: 173-191.
[4] BERMAN E F. The experimental replacement of portions of the esophagus by a plastic tube[J]. Annals of Surgery, 1952, 135:337-343.
pmid: 14903864
[5] LEE S, HWANG G, KIM T H, et al. On-demand drug release from gold nanoturf fora thermo-and chemotherapeutic esophageal stent[J]. ACS Nano, 2018, 12:6756-6766.
doi: 10.1021/acsnano.8b01921
[6] 於学婵, 沈秋霞, 卢珍珍, 等. 电纺丝技术制备组织工程食管仿生支架[J]. 中国组织工程研究, 2014, 18:4771-4776.
YU Xuechan, SHEN Qiuxia, LU Zhenzhen, et al. Preparation of tissue-engineered esophageal scaffolds using electrospinning technology[J]. Chinese Journal of Tissue Engineering Research, 2014, 18:4771-4776.
[7] LI J, YE W, FAN Z, et al. A novel stereocomplex poly(lactic acid) with Shish-Kebab crystals and bionic surface structures as bioimplant materials for tissue engineering applications[J]. ACS Applied Materials & Interfaces, 2021, 13(4):5469-5477.
[8] MENG J, BOSHETTO F, YAGI S, et al. Design and manufacturing of 3D high-precision micro-fibrous-poly (L-lactic acid) scaffold using melt electrowriting technique for bone tissue engineering[J]. Materials & Design, 2021. DOI:10.1016/j.matdes.2021.110063.
doi: 10.1016/j.matdes.2021.110063
[9] WEI P, XU Y, ZHANG H, et al. Continued sustained insulin-releasing PLGA nanoparticles modified 3D-printed PCL composite scaffolds for osteochondral repair[J]. Chemical Engineering Journal, 2021. DOI:10.1016/j.cej.2021.130051.
doi: 10.1016/j.cej.2021.130051
[10] CHEN P, CUI L, CHEN G, et al. The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair[J]. International Journal of Biological Macromolecules, 2019, 138: 79-88.
doi: S0141-8130(19)31768-4 pmid: 31295489
[11] PUTRI N, WANG X, CHEN Y, et al. Preparation of PLGA-collagen hybrid scaffolds with controlled pore structures for cartilage tissue engineering[J]. Progress in Natural Science: Materials International, 2020, 30: 642-650.
doi: 10.1016/j.pnsc.2020.07.003
[12] LAI Y, LI Y, CAO H, et al. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect[J]. Biomaterials, 2019, 197: 207-219.
doi: S0142-9612(19)30019-5 pmid: 30660996
[13] 王曙东, 张幼珠, 王红卫, 等. 静电纺PLA/丝素-明胶复合管状支架的结构与性能[J]. 纺织学报, 2009, 30(6):6-9.
WANG Shudong, ZHANG Youzhu, WANG Hongwei, et al. Study on the electrospun polylactide/silk fibroin-gelatin tubular scaffold for tissue engineering blood vessel[J]. Journal of Textile Research, 2009, 30(6):6-9.
[14] HU X, SHEN H, YANG F, et al. Preparation and cell affinity of microtubular orientation-structured PLGA(70/30) blood vessel scaffold[J]. Biomaterials, 2008, 29: 3128-3136.
doi: 10.1016/j.biomaterials.2008.04.010 pmid: 18439673
[15] LIN M, FIRROZI N, TSAI C, et al. 3D-printed flexible polymer stents for potential applications in inoperable esophageal malignancies[J]. Acta Biomateriali, 2019, 83: 119-129.
doi: 10.1016/j.actbio.2018.10.035
[16] SCHANER P J, MARTIN N D, TULENKO T N, et al. Decellularized vein as a potential scaffolds for vascular tissue engineering[J]. Journal of Vascular Surgery, 2004, 40: 146-153.
doi: 10.1016/j.jvs.2004.03.033
[17] LIU H, WANG S D, QI N. Controllable structure, properties, and degradation of the electrospun PLGA/PLA-blended nanofibrous scaffolds[J]. Journal of Applied Polymers, 2012, 125: E468-E476.
[18] 张锋, 张玉惕, 左保齐. 乙醇后处理对静电纺聚乳酸非织造网的影响[J]. 合成纤维, 2008(6):16-19.
ZHANG Feng, ZHANG Yuti, ZUO Baoqi. Effect of ethanol post-treatment on the characteristic of electrospun PLA nanofiber web[J]. Synthetic Fiber in China, 2008(6): 16-19.
[19] 王曙东. 静电纺PLA/丝素-明胶复合管状支架的构建及其性能[D]. 苏州: 苏州大学, 2009: 31-32.
WANG Shudong. Fabrication and properties of the electrospun polylactide/silk fibroin-gelatin composite tubular scaffold[D]. Suzhou: Soochow University, 2009: 31-32.
[20] BILLIAR K, MURRAY J, LAUDE D J. Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa[J]. Journal of Biomedical Materials Research Part A, 2001, 56:101-108.
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