Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (12): 16-21.doi: 10.13475/j.fzxb.20211106106

• Fiber Materials • Previous Articles     Next Articles

Structure and mechanical properties of three-dimensional porous biodegradable polymer artificial esophageal scaffold

WANG Shudong1,2,3()   

  1. 1. School of Textile and Clothing, Yancheng Polytechnic College, Yancheng, Jiangsu 224005, China
    2. College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215002, China
    3. Jiangsu Jinmaisui New Energy Technology Co., Ltd., Yancheng, Jiangsu 224000, China
  • Received:2021-11-11 Revised:2022-02-27 Online:2022-12-15 Published:2023-01-06

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Abstract:

In order to meet the requirements of artificial esophageal scaffolds on material's structure and mechanical properties, three-dimensional porous biodegradable polymer artificial esophageal scaffolds were prepared with biodegradable polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA) as raw materials, cylindrical polytetrafluoroethylene as template and sodium chloride as porogen. Morphology, microstructure and mechanical properties were characterized. The results show that the PLA and PLGA artificial esophageal scaffolds have three-dimensional porous structure. After ethanol treatment, the length, diameter and porosity of the esophageal scaffolds decrease to a certain extent. Microstructure of PLA and PLGA three-dimensional porous esophageal scaffolds is amorphous. Ethanol treatment improves the crystallinity of the two esophageal scaffolds to a certain extent. The breaking strength and suture strength of the PLA and PLGA esophageal scaffolds are (2.68±0.46) MPa, (3.68±0.98) N and (1.53±0.21) MPa, (2.21±0.65) N, respectively. After ethanol treatment, the tensile strength and suture strength of these two esophageal scaffolds are improved to a certain extent. The suture strength of the two esophageal scaffolds exceeds the suture strength that the scaffolds could bear during esophageal scaffolds transplantation.

Key words: artificial esophageal scaffold, polylactic acid, polylactic acid-glycdic acid copolymer, biodegradability, structure, mechanical property

CLC Number: 

  • TS102.512

Fig.1

Morphology photos of three-dimensional porous esophageal scaffolds. (a) PLA esophageal scaffold; (b) PLA-1#and PLA-2#; (c) PLGA esophageal scaffold; (d) PLGA-3# and PLGA-4#"

Tab.1

Size of three-dimensional porous esophageal scaffolds"

样品编号 长度/cm 管径/mm 壁厚/mm 孔隙率/%
1# 10.0 9.9 2.2 69.3
2# 9.9 9.8 2.1 61.9
3# 9.9 10.1 1.8 65.6
4# 9.8 9.9 1.7 58.3

Fig.2

SEM images of three-dimensional porous biodegradable polymer artificial esophageal scaffolds"

Fig.3

FT-IR spectra of three-dimensional porous esophageal scaffolds"

Fig.4

XRD spectra of three-dimensional porous biodegradable polymer artificial esophageal scaffolds"

Fig.5

Thermal properties of three-dimensional porous esophageal scaffolds. (a) TG curves; (b) TGA curves; (c) DSC curves"

Tab.2

Mechanical properties of three-dimensional porous esophageal scaffolds"

样品
编号		 断裂强
度/MPa		 断裂伸
长率/%		 弹性模
量/MPa		 缝合强
力/N
1# 2.68±0.46 38.56±3.35 6.95±0.35 3.68±0.98
2# 2.97±0.38 32.37±2.76 9.18±0.27 4.02±1.32
3# 1.53±0.21 46.79±4.21 3.27±0.23 2.21±0.65
4# 1.84±0.26 44.28±3.82 4.16±0.19 2.86±0.78
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