Abstract: To improve the spinnability of regenerated silk fibroin(RSF) solution,bromide-lithium/ethanol mixed solution was used as a solvent of silk fibroin,and the RSF solution containing xanthate was obtained by adding sodium ethyl xanthate.The RSF filament with xanthate was produced by wet spinning process.The effect of xanthate on the spinnability of the RSF solution was discussed,and the surface morphology of the RSF as-spun filament was observed by SEM.The results showed that compared with the RSF solution without xanthate the spinnability of RSF solution containing xanthate was improved obviously;the surface of RSF as-spun fiber containing xanthate became smooth,and the microfibrils of the fiber were apparently oriented along with fiber axis.