Abstract: The chemical stability of PVDF/PVC membrane by dry-wet spinning process was studied.The results showed that the flux of PVDF/PVC membrane increased after cleaning with sodium hypochlorite solution and the extent of increase was related to the concentration of the solution and acting time;PVDF/PVC membrane exhibitsed better resistant to acid and oxidizing than to alkali.In addition,cleaning of the fouled membrane was studied and it was found that chemical cleaning was more effective than hydraulic cleaning.The anti-fouling property of the membrane should be further improved.This paper has provided theoretical basis for applications of PVDF/PVC hollow fiber membrane.