Abstract: With an ordinary style of twelve men’s seamless underwear as the target of study, of which made with same style and material but different cylinder diameters, structures and knitting methods. The pressure and pressure comfort sense of different positions of a young man of M body size wearing underwear under static condition were tested. The objective and subjective evaluation methods, fuzzy mathematics, and box control graph were used to describe the pressure distribution of seamless underwear and summarize the relationship between pressure and comfort. The results show that in abdomen, leg and waist, the pressure is inversely proportional to the subjective evaluation, and proportional relation appears in side, hip and thigh. This may be attributed to the fact that different parts of the body have different pressure withstanding ability. It points out that the pressure on thigh, leg and waist should be decreased when designing men’s seamless underwear.