Abstract:

To solve the interference of complex matrix sample, determination method of Dimethyl Fumarate in textiles and leather products was established based on Gas Chromatography-Ion Trap mass spectrometry. Dimethyl Fumarate in sample was extracted with acetonitrile and purified by the Supleco PSA/SAX SPE column, and then qualitative and qualitative analyses were performed by the GC-MS/MS. Chemical ionization mode was selected with methanol as reagent gas, and the extraction solvent，purification and CID voltage used in the pretreatment were optimized. Threrfore, sensitivity and selectivity were greatly improved. Linearity between the peak area and concentration of dimethyl fumarate was obtained in the range of 0.05-10.0μg/mL (r=0.9998)，with its detection limit (LOQ) of 0.05mg/kg. External standard method was used in the quantitative analysis. Precision and recovery were tested by adding the standard dimethyl fumarate of 3 different concentration levels (50, 500, 1000μg/kg) to the leather samples, and analyzed by the proposed method, values of RSD (n=9) and recovery found were in the range of 3.52%-6.12% and 84.0%-99.5% respectively. The results showed that the proposed method was more sensitive and rapid, and no interference when compared with GC and GC-MS method. It can meet the analysis requirements of textile and leather samples in batches.