Journal of Textile Research ›› 2020, Vol. 41 ›› Issue (01): 26-31.doi: 10.13475/j.fzxb.20190200306

• Fiber Materials • Previous Articles     Next Articles

Preparation and properties of drug-loaded polyvinylidene fluoride wound dressings

WU Qianqian1,2, LI Ke1, YANG Lishuang1, FU Yijun1,2(), ZHANG Yu1,2, ZHANG Haifeng1,2   

  1. 1. School of Textile and Clothing, Nantong University, Nantong, Jiangsu 226019, China
    2. National & Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection,Nantong University, Nantong, Jiangsu 226019, China
  • Received:2019-01-29 Revised:2019-10-24 Online:2020-01-15 Published:2020-01-14
  • Contact: FU Yijun E-mail:fyjviolin@163.com

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Abstract:

With the aim of obtaining thin and soft wound dressings with excellent piezoelectric and antibacterial functions, drug-loaded (PVDF) composite nanofiber membranes were prepared by electrospinning from PVDF and enrofloxacin hydrochloride (Enro) at different mass ratios. The influence of morphology and chemical structure of the composite nanofiber membrane on its piezoelectricity, sustained release and antibacterial properties were investigated. Results show that in the situation where the mass ratio of PVDF was 8% and the average fiber diameter was(753±128) nm, the fiber membrane showed good web formation. It is revealed that the diameter of composite nanofiber increased and then decreased as the Enro mass fraction was incremented, and that the crystal structure of PVDF changed from α to β crystal phase after the process of electrospinning, leading to an excellent piezoelectric properties with a 9 mV output voltage. When the mass concentration of Enro was 15%, the drug-loaded PVDF composite nanofiber membrane exhibited a relatively stable and sustainable release and outstanding antibacterial performance. The drug-loaded PVDF composite nanofiber membrane is proven to be suitable for wound dressings.

Key words: wound dressings, polyvinylidene fluoride, enrofloxacin hydrochloride, electrospinning, piezoelectric property, antibacterial property

CLC Number: 

  • TS174.8

Fig.1

SEM images of PVDF nanofiber membranes with different mass concentrations(×5 000)"

Fig.2

SEM images of PVDF/Enro composite nanofiber membrane with different mass concentrations of Enro(×8 000)"

Fig.3

Infrared spectra of PVDF powder, Enro powder, pure PVDF nanofiber membrane and PVDF/Enro composite nanofiber membrane"

Fig.4

X-ray diffraction patterns of different fiber membranes and PVDF powders"

Fig.5

Output voltage of PVDF/Enro composite nanofiber membrane with different mass concentrations of Enro"

Fig.6

Standard curve of Enro"

Fig.7

Simulated cumulative release curve of different fiber membranes in vitro"

Fig.8

Flora density of PVDF nanofiber membrane before and after drug loading"

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