Journal of Textile Research ›› 2021, Vol. 42 ›› Issue (08): 175-184.doi: 10.13475/j.fzxb.20200606110

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Research progress of high-molecular polymer material for bone defect repair

SUN Yusheng1, ZUO Baoqi1,2()   

  1. 1. College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215123, China
    2. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China
  • Received:2020-06-22 Revised:2021-05-08 Online:2021-08-15 Published:2021-08-24
  • Contact: ZUO Baoqi E-mail:bqzuo@suda.edu.cn

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Abstract:

In order to develop bone defect-repairing materials with good biocompatibility, excellent mechanical properties and property stability, the types, properties, advantages and disadvantages as well as future research trends of bone defect-repairing materials were reviewed. This paper firstly summarizes the recent research progress in preparation of bone defect-repairing materials by polymers such as silk fibroin, chitosan, collagen, polyvinyl alcohol, polycaprolactone, and polylactic acid and its derivatives. In view of applications in the treatment of osteomyelitis in repairing bone defects, shortcomings of the materials and the research gaps were analyzed. It is concluded that the development of bone defect-repairing materials are multidisciplinary, and the repair materials made from natural and synthetic high-molecular polymers can greatly promote their applications in bone tissue engineering. It is also pointed out that inorganic materials such as graphene, graphene oxide, titanium dioxide, hydroxyapatite are expected to become the research focuses of bone defect-repairing materials in the future.

Key words: bone tissue engineering, bone defect-repairing material, silk fibroin, natural high-molecular polymer, synthetic high-molecular polymer, osteomyelitis

CLC Number: 

  • R318.08

Tab.1

Commonly used scaffolds for bone defect repair"

复合支架 目的 文献
负载万古霉素明胶基复合支架 通过万古霉素杀灭致病菌达到治疗骨髓炎目的 [8]
壳聚糖/透明质酸、纳米珍珠粉复合支架 在组成以及结构上模拟骨组织达到治疗硬骨缺损目的 [9]
竹纤维/羟基磷灰石/聚乳酸乙醇酸复合支架 提高支架孔隙率以及成骨效应 [10]

Tab.2

Solubility of silk fibroin protein"

溶解方式 特点
氯化钙/乙醇/水 对丝素蛋白没有严重降解作用,无毒且高效
溴化锂 溴化锂溶解的丝素蛋白比通过氯化钙/乙醇/水三元溶解体系溶解的丝素蛋白具有更高的分子质量[17]
甲酸/氯化钙 可直接将丝素分解成微纳米纤维,且丝素蛋白纳米纤维的形貌与氯化钙浓度密切相关,材料在干燥以及潮湿状态下具有良好的力学性能[16]

Tab.3

Recycling material of polymer for bone defect repair"

硬骨缺损修复
再生材料		 种类 文献
天然高分子聚合物 胶原蛋白、壳聚糖、透明质酸 [27-30]
合成高分子聚合物 聚乙烯醇、聚己内脂、聚乳酸及其衍生物 [31-33]
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