Journal of Textile Research ›› 2021, Vol. 42 ›› Issue (08): 41-48.doi: 10.13475/j.fzxb.20200901308

• Fiber Materials • Previous Articles     Next Articles

Preparation and characterization of silk fibroin hydrogel in acid-alcohol system

LIU Hao1, LU Minglei1, HUANG Xiaowei1,2, WANG Na1,2, WANG Xuefang1,2, NING Xin2,3, MING Jinfa1,2,3()   

  1. 1. College of Textiles & Clothing, Qingdao University, Qingdao, Shandong 266071, China
    2. Industrial Research Institute of Nonwovens & Technical Textiles, Qingdao University, Qingdao, Shandong 266071, China
    3. Shandong Special Nonwoven Materials Engineering Research Center, Qingdao, Shandong 266071, China
  • Received:2020-09-04 Revised:2021-04-28 Online:2021-08-15 Published:2021-08-24
  • Contact: MING Jinfa E-mail:mingjinfa@qdu.edu.cn

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Abstract:

In order to achieve the controllable morphology of silk fibroin hydrogel and to improve the gelling speed and compression properties, a simple fabrication method for silk fibroin hydrogel in acid-alcohol system was developed. This paper reports the effect of alcohol with different mass ratio on the morphology, aggregation structure, thermal property and compressive property of hydrogel at the same acidic condition. The research explored the forming conditions for silk fibroin hydrogels, and the differences in structure and properties of hydrogel. The results show that the structure and properties of hydrogels are improved with increased use of alcohol, which also benefited the gelation time reduction from 12-14 h to 1 h. In relation to this, the morphology of hydrogel gradually changes from pore to fibrous state. Moreover, the crystallization structure of silk fibroin in hydrogels was found to be mainly β-sheet. When the mass ratio of alcohol was set to 5.0%, the fiber diameter reached (1.09±0.5) μm. The hydrogels demonstrated a compressive strength of (75.16±3.79) kPa at 60% strain in dry state, and the compression recovery rate reached 63% in wet state.

Key words: silk fibroin, hydrogel, acid-alcohol system, compression property, crystallization structure, medical material

CLC Number: 

  • TS109

Tab.1

Specification parameters of silk fibroin hydrogels"

样品
名称		 SF质量
分数/%		 乙醇质量
分数/%		 温度/
℃		 冻干后成
形状况
SF-0 3 0.0 25 成形良好
SF-1 3 1.0 25 成形良好
SF-2.5 3 2.5 25 成形良好
SF-5 3 5.0 25 成形良好
SF-10 3 10.0 25 成形良好
SF-20 3 20.0 25 未成形

Fig.1

SEM images of SF hydrogels with different mass ratios of alcohol"

Fig.2

Raman pattern of SF hydrogels with different mass fraction of alcohol"

Fig.3

Secondary structure of SF hydrogels with different mass fraction of alcohol.(a)FT-IR spectra of SF hydrogels;(b)FT-IR peak fitting curve of SF-5 hydrogel in amide Ⅰ region;(c)Change of secondary structure of SF hydrogel in amide Ⅰ region"

Fig.4

XRD pattern of SF hydrogels with different mass fraction of alcohol"

Fig.5

DSC (a) and TG (b) curves of SF hydrogels prepared by different mass ratios of alcohol"

Fig.6

Compressive property of SF hydrogels in dry and wet state. (a) Compressive property in dry state; (b) Cyclic compressive property in wet state"

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