Abstract: Drug loaded composite nanofibers of PLA/SF were prepared via electrospinning by dissolving aspirin,polylactide (PLA) and silk fibroin (SF) in binary solvent of trifluoroacetic acid and dichloromethane at a volume ratio of 7/3.The films were characterized by scanning electron microscope (SEM) and infrared spectroscopy (IR),and the absorbency of drug in PBS solution was detected by UV-visible spectroscopy, then counting the velocity of drug release.It was found that the average diameter of the blended nanofibers become fine with the content of drug increasing,PLA and SF can be composited very well and releasing rate reaches the maximum when containing SF with 3% and increases with the aspirin content growing.

Key words: electrospinning, polylactide, silk fibroin, controlled-release of drug