Abstract: To establish a method for the determination of dimethyl fumarate in textiles by solid phase extraction- high performance liquid chromatography. The samples were used by Ultrasonic Extraction, cleaned and enriched by a Sep-Pak? Vac Silica solid-phase extraction(SPE) cartridge, separated on a Kromasil C18 column（250 mm × 4.6 mm i.d., 5 μm）by using the mobile phase consisting of CH3CN+H2O (55+45, V/V) . Detection was performed by 220 nm using extenal standard method. The result of experiment shows that calibration curve of dimethyl fumarate was linear within the range of 0.05~50.0 mg/L , the limit of detection was found to be 0.05mg/kg,and the limit of quantification was found to be 0.15 mg/kg. The extraction recoveries were at 91.2 ~ 102.1% , average recoverywas 96.4% and the RSDs were at 1.3~3.9%. The developed method is quick，simple, little interferential for the determination of dimethyl fumarate residue in textiles.

Key words: textile, dimethyl fumarate, SPE, HPLC