Abstract:

The regenerated bacterial cellulose（RBC）fiber used for wound dressing and having good biocompatibility was prepared by a wet spinning process，taking bacterial cellulose as raw material, adopting LiCl/Dimethylacetamide as solvent system and using water as coagulation bath. Then ciprofloxacin was used as model drug to prepare drug-loaded RBC fiber. The characterization of morphological, mechanical properties, XRD, drug loading and release performance were determined. The results shows that the RBC fiber had a groove surface structure with a diameter of about 40 μm. The tensile breaking strength of the RBC fiber is as high as 2.5 cN/dtex. X-ray diffraction results indicated that the crystal form of RBC fiber is transformed from cellulose crystalⅠto Ⅱ, and the degree of crystallinity is reduced from 66.3% to 36.2%. The drug loading and release experiments show that the RBC fiber had the highest drug loading capacity under alkaline condition, while the drug loaded RBC fiber has the largest release amount under acid condition.

Key words: regenerated bacterial cellulose fiber, wet spinning, drug-loaded fiber, biomedical materials