Aiming at short storage time and high transportation cost of the color paste for spun-dyed viscose fibers, the self-dispersing Phthalocyanine Blue 15:3 pigment powder were prepared by the spray drying method. The effects of the spray drying parameters including air inlet temperature, feeding rate, pressure and air flow rate on the properties of self-dispersing pigment were discussed. In addition, transmission electron microscope (TEM) and scanning electron microscope (SEM) were employed to study the apparent morphology, and the dispersion state of self-dispersing pigments in viscose fiber was investigated. The results show that when the inlet air temperature is 165 ℃, the feeding rate is 10 mL/min, the pressure is 0.2 MPa, and the air flow rate is 2.95 m3/min, particle size of the self-dispersing Phthalocyanine Blue 15:3 pigment powder is 171 nm, and the water contact angle is 13°. The pigments show excellent self-dispersing properties, and the centrifugal, acid and alkali resistance, heat resistance and salt resistance stability are all above 80%. The self-dispersing Phthalocyanine Blue 15:3 deminstrates a good interface compatibility with the viscose spinning solution and is homogeneously dispersed in the spun-dyed viscose fiber. The color fastness against rubbing and washing reach grade 4.